ID K7FJT2_PELSI Unreviewed; 700 AA.
AC K7FJT2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|Ensembl:ENSPSIP00000008292.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008292.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR EMBL; AGCU01070542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01070543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FJT2; -.
DR STRING; 13735.ENSPSIP00000008292; -.
DR Ensembl; ENSPSIT00000008335.1; ENSPSIP00000008292.1; ENSPSIG00000007600.1.
DR eggNOG; ENOG502QRKR; Eukaryota.
DR GeneTree; ENSGT00390000008048; -.
DR HOGENOM; CLU_023578_1_0_1; -.
DR OMA; QTHEEGY; -.
DR TreeFam; TF331165; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0061474; C:phagolysosome membrane; IEA:Ensembl.
DR GO; GO:0022829; F:wide pore channel activity; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..700
FT /note="Macrophage-expressed gene 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901806"
FT TRANSMEM 642..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..345
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 700 AA; 75159 MW; 575046003DDFFD41 CRC64;
MKMLLGALLS WGLVAWVKGA EKPPGPPAVM GLQECKKALK LSGLEVLPGG GWDNLRNLDM
GRVISLGYSQ CKTTEDGSYL IPDEVFTIPR KQSNLEINSE LIESWRDYQS ATAASVNGEV
SLFSSLNGKF SSDFHKMKTH QVKDQAVTTR VQVRNLVYTA KFDPAAALDK GFHQQLVAIA
GHLENNQSRM ADYLAEMLVL NYGTHVVTSV DAGASLVQED QIKSAFVQDS MSTRSAITAS
AGASFHSIID FNIGGSLSTQ DAFTKQYLAN RTNSRVESIG GVPFYPGITL KAWQEGTANQ
LVAIDRSGLP LHFFITPSSA PELATRRYYI FNTYPGCTDA ASPNFNFHAN TDDGSCTGAG
TNFTFGGAYQ ECAPLMGPDA PVLCQGLEQR NPLTGAFSCP AGYIPVRLST QEREEGYSHL
ECRNSCVLGL FCKRVCKDVF WLSKVQFSAF WCMARSQVPE NSGYLFGGLF SSRSVNPMTN
AQSCPSSFFQ LKLFDQLQLC VSRDYETGFR HSVPFGGLFS CEMGNPLAGA HQGTANDPYL
KRCPAGFSQH LALISDGCQV DYCVQSGIFT GGALPPARLP PYTRPPAIAS VGTDTVLVTS
VDGARSWVKD AQTQLWRLGG PAETRRAAGL GGGGGLSGGE TAGVTVGVTT GLAFLIALAI
YGSRRLKARG YRRVEEGQSL IPGSAAYGTA AELGESCQPD
//
