ID K7FK75_PELSI Unreviewed; 672 AA.
AC K7FK75;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=FMR1 autosomal homolog 1 {ECO:0000313|Ensembl:ENSPSIP00000008435.1};
GN Name=FXR1 {ECO:0000313|Ensembl:ENSPSIP00000008435.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008435.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR EMBL; AGCU01198621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01198627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000008435; -.
DR Ensembl; ENSPSIT00000008479.1; ENSPSIP00000008435.1; ENSPSIG00000007616.1.
DR eggNOG; ENOG502QPKJ; Eukaryota.
DR GeneTree; ENSGT00950000183189; -.
DR HOGENOM; CLU_020699_3_0_1; -.
DR OMA; WPARITK; -.
DR TreeFam; TF105427; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0043034; C:costamere; IEA:Ensembl.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005840; C:ribosome; IEA:Ensembl.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR GO; GO:1905538; F:polysome binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0033592; F:RNA strand annealing activity; IEA:Ensembl.
DR GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR GO; GO:0061157; P:mRNA destabilization; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:1900272; P:negative regulation of long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0140694; P:non-membrane-bounded organelle assembly; IEA:Ensembl.
DR GO; GO:0051292; P:nuclear pore complex assembly; IEA:Ensembl.
DR GO; GO:0051664; P:nuclear pore localization; IEA:Ensembl.
DR GO; GO:2000637; P:positive regulation of miRNA-mediated gene silencing; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
DR GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
DR GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd22504; KH_I_FXR1_rpt1; 1.
DR CDD; cd22507; KH_I_FXR1_rpt2; 1.
DR CDD; cd22510; KH_I_FXR1_rpt3; 1.
DR CDD; cd20475; Tudor_Agenet_FXR1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR032177; FXR_C3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047494; KH_I_FXR1_rpt1.
DR InterPro; IPR047495; KH_I_FXR1_rpt2.
DR InterPro; IPR047496; KH_I_FXR1_rpt3.
DR InterPro; IPR047427; Tudor_Agenet_FXR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF6; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF16097; FXR_C3; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 3..50
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 63..115
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 380..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 75824 MW; AD44C144177A1AF2 CRC64;
MQLSGRAETS SLLQEKSGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIG
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT
VKKNTFFKCT VDVPEDLRDA CANENAHKDF KKAVGACRIF YHAETMQLII LSASEATVKR
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN
IQQARKVPGV TAIELEEDTG TFRIYGESAD AVKKARSYLE FVEDFIQVPR NLVGKVIGKN
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KENIGNVQVL LEYHIAYLKE
VEQLRLERLQ IDEQLRQIGM GFRPSSSRGP EKEKGYATDE STLXXXXGRG RRGPNYTSGY
EGTNSELSNP SETESERKDE LSDWSLAGED DRESRHQRDS RRRPGGRGRS VSGGRGRGGP
PRGGKSSISS VLKDPDSNPY SLLDNTESDQ TVDTDASESH HSTNRRRRSR RRRTDEDAVL
MDGMTESDTA SVNENGLDDS DKKPQRRNRS RRRRFRGQAE DRQPVTVADY ISRAESQSRQ
RNLPRETLVK NKKETVKDVI EEHTPPEKAI NGPANAPGDE PSNPQNSPEE EKSSTIQEDE
NNPEEAVLNG VS
//
