ID K7FMA2_PELSI Unreviewed; 855 AA.
AC K7FMA2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009162.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009162.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; AGCU01036132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01036141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FMA2; -.
DR STRING; 13735.ENSPSIP00000009162; -.
DR Ensembl; ENSPSIT00000009208.1; ENSPSIP00000009162.1; ENSPSIG00000007969.1.
DR eggNOG; KOG1172; Eukaryota.
DR GeneTree; ENSGT00940000159765; -.
DR HOGENOM; CLU_002289_1_0_1; -.
DR OMA; HKLWRPP; -.
DR TreeFam; TF313630; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR018241; Anion_exchange_CS.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF15; ANION EXCHANGE PROTEIN 3; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS00219; ANION_EXCHANGER_1; 1.
DR PROSITE; PS00220; ANION_EXCHANGER_2; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 359..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 410..435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 518..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 555..572
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 705..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 730..751
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 778..795
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 801..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 1..235
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 297..784
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 90..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 94679 MW; 5005DAFE43FAE7E5 CRC64;
GAVLLDLEQT TLPGIAHLVV ETMIISDQIK EEDRANVLRA LLLKHSHPND EKEGFFPHNH
SSSSVNSIAG NHHHNHNHAG DTCLPLMEPL PSIPRREESD PVVPQSQPPA CTEGHRGKHV
KLLEKIPDDA EASVVLVGCV QFLEQPTMAF VRLNEAVFLE SVLEVPIPVR FIFVLLGPSQ
ANVDYHEIGR SIATLMSDKL FHEAAYMADD RQDLLNAINE FLDCSIVIPP SEVEGKDLLR
SIATFQKELL RKRKESPSRV PVVTTMHRTP AELCEVKAEE EEEGDAEDDP LRRTGICFGG
LVRDIKRRYP KYLSDLRDAL HSQCLAAVLF IYFAALSPAI TFGGLLGEKT EGLMGVSELI
ISTSVLGILF SLLGAQPLLV IGFSGPLLVF EEAFFKFCQS QGIEYLTGRV WIGLWLIVFI
FIIVAAEGSF LVRYISPFTQ EIFAFLISLI FIYETFYKLY QVTLPREMCC LRACRGSGVP
GHGTSFLFLP QLPGVGQSGA GLSGEYGDGL ARMQPNTALL SLILMLGTFF IAFFMRKFKN
SRFLGGKARR IIGDFGIPIS ILVMVLVDYS ITDTYTQKLN VPTGLSVTAP QKRGWFIHPL
GSGQAFPMWM MFASAIPALL VFILIFMETQ ITTHSCTPGL HPHLHGDPDH HVSVAACGPR
AVWGLAELQG EEAQSGTHVN ALTVMSKAIA PGEKPKIEEV KEQRVTGVAI AVLVAGCAVQ
PGALLAPIPL AVLFGIFLYM GVTSLTGIQL YERLLLIFMP SKHHPDHIYV VKVKTWRMHL
FTCIQLACIV VLWVVKSTVA SLAFPFVLIL TVPLRRFLLP RFFQDRELKA LDSEDAEPNF
DEDGRDEYNE MHMPV
//
