ID K7FMV0_PELSI Unreviewed; 729 AA.
AC K7FMV0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 1 {ECO:0000313|Ensembl:ENSPSIP00000009360.1};
GN Name=LRFN1 {ECO:0000313|Ensembl:ENSPSIP00000009360.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009360.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009360.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the LRFN family.
CC {ECO:0000256|ARBA:ARBA00038433}.
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DR EMBL; AGCU01170294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01170295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01170296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01170297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006135825.1; XM_006135763.1.
DR AlphaFoldDB; K7FMV0; -.
DR STRING; 13735.ENSPSIP00000009360; -.
DR Ensembl; ENSPSIT00000009406.1; ENSPSIP00000009360.1; ENSPSIG00000008532.1.
DR GeneID; 102458729; -.
DR KEGG; pss:102458729; -.
DR CTD; 57622; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160922; -.
DR HOGENOM; CLU_016998_0_1_1; -.
DR OMA; APVEVCI; -.
DR OrthoDB; 2942402at2759; -.
DR TreeFam; TF350185; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF7; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..729
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901933"
FT TRANSMEM 521..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..375
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 414..509
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 387..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 80949 MW; 1424B5FD9869D667 CRC64;
MEKLLLPLLM LGSMVKAQHC PGRCICQNIS PTLTMLCAKT GLLFVPPSID RRTVELRLTD
NFITIIRRKD FSNMTNLVHL TLSRNTISQV MPYAFADLRS LRALHMNSNR LAALRNEHFK
GLGNLRHLIL GNNQISNIQP ASFNEFLATV EDLDLSYNNL ETLPWEAIGQ MVSLNTLTLD
HNLIDHIAEG TFSQLHKLVR LDMTSNRLQK LPPDNLFLRA QVLANVRGSH PSTLTISFGG
NPLHCNCELL WLRRLTREDD LETCASPEHL MDKYFWSIPE EEFICEPPLI TRQYSTKAFI
MEGQGVSLKC KAVGDPDPSI HWIAPDGKLI HNTTRTTVYD NGTLEVHITT LKDNGVFTCI
ASNAAGEATA PVEVCIVPLP LLVNNTGHMK EPDPGSSDIT TSAKSGTNDT KNHLDKKIVA
AELSSTSVVI HWPSERHIPG IRMYQIQYNS SLDDSLVYRM IPPSSRAFLV NDLAAGRAYD
LCVLAVYDDG VTALTATRVV GCVQFTTEGE TAQCHALHTQ FLGGTMIIII GGIIVASVLV
FIIILMIRYK VHSGQEGHKK AKVSNVYSQT NGGQPPASKT TEDKYETFQE AEPKEAGPVE
VEPKEAGPKE DTPTAPEQDK RDLKPGADLQ TVALLSSEEG QPKGQERGPG SQHRATLGSV
GLFPRELSRT HHHRHSFDGD YSLFQSHSYP RRARTKRHMS TSQLNTEDCP LSQRRVTFSS
TEWMLESTV
//
