ID K7FNL1_PELSI Unreviewed; 899 AA.
AC K7FNL1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H3 {ECO:0000256|ARBA:ARBA00039924};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009621.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009621.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC protein between hyaluronan and other matrix protein, including those on
CC cell surfaces in tissues to regulate the localization, synthesis and
CC degradation of hyaluronan which are essential to cells undergoing
CC biological processes. {ECO:0000256|ARBA:ARBA00037051}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR EMBL; AGCU01116377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01116378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01116379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FNL1; -.
DR STRING; 13735.ENSPSIP00000009621; -.
DR Ensembl; ENSPSIT00000009668.1; ENSPSIP00000009621.1; ENSPSIG00000008164.1.
DR eggNOG; ENOG502QPS2; Eukaryota.
DR GeneTree; ENSGT00940000154554; -.
DR OMA; FNVIRFD; -.
DR TreeFam; TF328982; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..899
FT /note="Inter-alpha-trypsin inhibitor heavy chain H3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901979"
FT DOMAIN 29..158
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 283..466
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 605..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 100680 MW; 071761E06E2B45F3 CRC64;
MANHLLFYIL LALIPALGTS DFLITQFRNI KKRSADDLIV NGIEIYSMKI DSKVTSRFAH
NVITSRAVNR ANVSKEVVFD VDLPKTAFIT NFSMIIDGVT YPGTIKEKEV AKKQYEKAVS
RGQTAGLVKA SGRKTEKFTV SVNIAAASKV TFELVYEELL KRNFGKYEMF IKVKPKQLVK
NFEIEVNIFE PQGISELDAQ GSFVTNDLSQ VLTKSFSGKK GHVSFKPTLD QQRTCATCST
SLLDGDFIIK YDVKRDSPGD LQIVNGYFVH FFAPTNLPRF PKNVIFVIDI SGSMDGIGIQ
QTRQALLKIL EDIKEEDYFN FILFGTDVHV WKDKLVQATP ENLKEAKEFA QAISTRGMTN
LHGGLMKGIE MLNTAYETNS VPKRSASIII MLTDGQPNQG VSDPQQIQAN VKTAIQGKYP
LYNLAFGYGI DYNFLEKMAL ENKGVARRIY PDSDSAIQME GFYDEVANPM LTEVELNYPE
NAIADLTQNN FKHYYDGSEI VVAGRITDND LNSLTADVKA QGALNDVTYI EQADVNEMAK
ALQEQEYIFG DYIERLWAYL TIQQLLEKRT VAQGEEKDNL TAEALELSLK YKFVTPLTSM
VVTKPEDNED QSAIADKPVE GKAKAAPGTY SAPTHSFLYS RPASPSVYTS VDGDPHFIIS
VPQKEDAICF NINEETGTVL SLIKDPVTGI TVNGQLIGDK RVNNDAKIQN TYFGKLGIEN
KKLELKLEVT PEKIIIQNGR KKTVFSWLDT VTLRQESLTL IINRKKNLVL SMGDGASFVI
VLHQVWEKHP LHQNFLGLYT LDSHKLSEHT HGLLGQFFHH IDFDILEIHP GADSKKPDAT
MMVKNNKLTV TRGWQKDFRK DSQHGVDIPC WFVHNNGAGL IDGVHTNYIV SSIFDTTIN
//
