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Database: UniProt
Entry: K7FNX3_PELSI
LinkDB: K7FNX3_PELSI
Original site: K7FNX3_PELSI 
ID   K7FNX3_PELSI            Unreviewed;      2202 AA.
AC   K7FNX3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-OCT-2017, entry version 41.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSPSIP00000009733};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
OC   Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009733, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Ensembl:ENSPSIP00000009733}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17381049; DOI=10.1080/10425170600760091;
RA   Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
RT   "The complete mitochondrial genome of the Korean soft-shelled turtle
RT   Pelodiscus sinensis (Testudines, Trionychidae).";
RL   DNA Seq. 17:471-483(2006).
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000009733}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPSIP00000009733}.
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DR   EMBL; AGCU01112461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01112470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 13735.ENSPSIP00000009733; -.
DR   Ensembl; ENSPSIT00000009780; ENSPSIP00000009733; ENSPSIG00000008742.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007267};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    261       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    388    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    414    432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    592    614       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1043   1062       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1074   1092       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1113   1132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1178   1200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1290   1315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1371   1389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1401   1424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1495   1513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1588   1612       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1628   1663       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      610    637       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2202 AA;  249394 MW;  31233B05B0C8B5A6 CRC64;
     PFEYMILATI IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFV
     FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRTL RAVRVLRPLK LVSGIPSLQI
     VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR ACYTNNSGEL EELDPPHPCG
     VQGCPSGYEC KEWIGPNDGI TQFDNILFAV LTVFQCITME GWTTVLYNTN DALGATWNWL
     YFIPLIIIGS FFVLNLVLGV LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK
     AEEVMLAEEN KNAGTSALEV LRRATIKRNR TEAMNRDSSD EHCVDISSVG TPLARGSIRS
     AKVDGASYFR HKERLLRISV RHMVKSQVFY WIVLSLVALN TACVAIVHHN QPPWLTHILY
     YAEFLFLGLF LLEMSLKMYG MGPRLYFHSS FNFFDCGVTV GSIFEVVWAI FRPGTSFGIS
     VLRALRLLRI FKVTKYWASL RNLVVSLMSS MKSIISLLFL LFLFIVVFAL LGMQLFGGRF
     NFMDGTPSAN FDTFPAAIMT VFQILTGEDW NEVMYNGIRS QGGVRSGMWS SIYFIILTLF
     GNYTLVNVFL AIAVDNLANA QELTKDEQEE EEAFNQKHAL QKAKEVSPMS APNMPALERD
     RRRRHHMSMW EPRSSQLRDR RRRHHMSVWE QRTSQLRRHM QMSSQEGLNK DAPPLINPHA
     SIFRRKKPGE NAGEKSEEDQ GGRAEQPPGE GLEQPTADTN ACPSAKEDQK TPSPRAKRDR
     EQWHQKSCHG NCDGTEPEGA GRGGGAGMED RARLRQSQRR SRHRRMRTEG KEAAGALESR
     SASQEVGLEE VNPTDGEQAR KEGEKADVIQ EEPLAGEEQD RTSDIPAGDA AFAGAMKETS
     PLRAPQELSP EKNESLAEQD CSGLDTSDQA LLGSVQLEMS RAVSRSEPEL SSVTAHTEKA
     TESTTIMIDV QDSAVVQISN KTDGEASPLK EAEAKEVEAK EKKRKKEKSS RSGKAMVPHS
     SMFIFSTTNP VIALTHYIVN LRYFEMCILL VIAASSIALA AEDPVLTNSD RNKVLRYFDY
     VFTGVFTFEM IIKMIDQGLI LRDGSYFRDL WNILDFIVVV GALVAFALAN TLGTNKGRDI
     KTIKSLRVLR VLRPLKTIKR LPKLKAVFDC VVTSLKNVFN ILIVYKLFMF IFAVIAVQLF
     KGKFFYCTDS SKDTEKDCIG NYVDHEKNKM EVKCREWKRH EFHYDNIIWA LLTLFTVSTG
     EGWPQVLQHS VDVTEEDRGP SRSNRMEMSI FYVVYFVVFP FFFVNIFVAL IIITFQEQGD
     KMMEECSLEK NERACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE YTIMAMIALN
     TVVLMMKYYS APYTYELALK YLNIAFTMVF SLECVLKIIA FGFLNYFRDT WNIFDFITVI
     GSITEIILTD TKLVNTSSFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
     LLIAMLFFIY AIIGMQVFGN IKLDEESHIN RHNNFRSFLA SLMLLFRSAT GEAWQEIMLS
     CLEGKGCEPD TTATSGQSQN EHCGTDLAYV YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR
     DSSILGPHHL DEFVRIWAEY DRAACGRIHY TEMYEMLTLM SPPLGLGKRC PSKVAYKRLV
     LMNMPVAEDM TVHFTSTLMA LIRTALDIKI AKGGADWQQL DSELQKEILA IWPHLSQKML
     DVLVPLPKTT DLTVGKIYAA MMIMDYYKQS KAKKQRQQLE EQKNAPMFQR MEPSSLPPEI
     LSNAKALPFL QQSPVSSIGS SRSGYPSMSP LSPQEIFQLA CMDPTHGQFQ EQQSLEPEVR
     EFQRVQPSNR GNYLPVDTQE RAVAGRASSM PRLTVDPQVV TDTSSMRRSF STIRDKRPNS
     SWLDEFSMER SSENTYKSRR RSYHASLQLS ARRLNADAGH RSETHRAGGR ERGRSKERKH
     LLSPDISRCN SEERSPQAEG ESPVRRQSRS PSEGRSQTPN RQGTGSLSES SIPSISDTST
     PRRGRRQLPP VPPKPRPLLS YASLMRHSGD TSPQPDESEG GSPLFSQVLE MNDTCLTESS
     SSPPGKQSRH STPQRYISEP YLALHDDSHA SDCGEEETLT FEAAVATSLG RSNTIGSAPP
     LRHGWQMPNG HYRRRRRGAA AQGVMCGASI DVLSDTEEDD KC
//
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