ID K7FRQ9_PELSI Unreviewed; 178 AA.
AC K7FRQ9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Anterior gradient 2, protein disulphide isomerase family member {ECO:0000313|Ensembl:ENSPSIP00000010719.1};
DE SubName: Full=Anterior gradient-like protein 2 {ECO:0000313|EMBL:AGG20189.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010719.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|EMBL:AGG20189.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23412115; DOI=10.1038/srep01279;
RA Ivanova A.S., Tereshina M.B., Ermakova G.V., Belousov V.V., Zaraisky A.G.;
RT "Agr genes, missing in amniotes, are involved in the body appendages
RT regeneration in frog tadpoles.";
RL Sci. Rep. 3:1279-1279(2013).
RN [4] {ECO:0000313|Ensembl:ENSPSIP00000010719.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AGR family. {ECO:0000256|ARBA:ARBA00038124}.
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DR EMBL; AGCU01197337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JX854518; AGG20189.1; -; mRNA.
DR RefSeq; NP_001273859.1; NM_001286930.1.
DR RefSeq; XP_014436665.1; XM_014581179.1.
DR STRING; 13735.ENSPSIP00000010719; -.
DR Ensembl; ENSPSIT00000010773.1; ENSPSIP00000010719.1; ENSPSIG00000009717.1.
DR GeneID; 102445292; -.
DR KEGG; pss:102445292; -.
DR CTD; 10551; -.
DR eggNOG; ENOG502RYQ8; Eukaryota.
DR GeneTree; ENSGT00530000063273; -.
DR HOGENOM; CLU_088048_1_1_1; -.
DR OMA; YSNMQKA; -.
DR OrthoDB; 101767at2759; -.
DR TreeFam; TF321449; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0002162; F:dystroglycan binding; IEA:Ensembl.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0060480; P:lung goblet cell differentiation; IEA:Ensembl.
DR GO; GO:0070254; P:mucus secretion; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0048639; P:positive regulation of developmental growth; IEA:Ensembl.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1903896; P:positive regulation of IRE1-mediated unfolded protein response; IEA:Ensembl.
DR GO; GO:1903899; P:positive regulation of PERK-mediated unfolded protein response; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR CDD; cd02960; AGR; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR15337:SF1; ANTERIOR GRADIENT PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR15337; ANTERIOR GRADIENT PROTEIN-RELATED; 1.
DR Pfam; PF13899; Thioredoxin_7; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..178
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014099484"
SQ SEQUENCE 178 AA; 20371 MW; 6C6F239F267D150B CRC64;
MEKTGISVFL LLVAVSYTLA KDFTAKNGAK RDTKEVPETK PKLPQTLSRG WGDNLIWTQT
YEEALFRAKT GNKPLMIIHH LEDCPHSQAL KKVFAEHKEI QKLAEKFVLL NLVYETTDKH
LSPDGQYVPR IMFIDPSLTV RADITGRYSN RLYAYEPSDI SLLYSNMQKA LKLLKTEL
//
