ID K7FS94_PELSI Unreviewed; 768 AA.
AC K7FS94;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Very low density lipoprotein receptor {ECO:0000313|Ensembl:ENSPSIP00000010904.1};
GN Name=VLDLR {ECO:0000313|Ensembl:ENSPSIP00000010904.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010904.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000010904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGCU01132528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01132529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FS94; -.
DR Ensembl; ENSPSIT00000010960.1; ENSPSIP00000010904.1; ENSPSIG00000009633.1.
DR GeneTree; ENSGT00940000155460; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 692..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 287..322
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 418..460
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 461..504
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 505..547
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 25..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 45..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 52..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 64..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 84..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 91..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 137..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 149..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 217..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 291..301
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 768 AA; 84506 MW; BA301252A43444F0 CRC64;
MRTCRVNDIS CGPRSAQCIP ASWKCDGEKD CDSGEDEENC GNVTCSPAEF TCSNGQCISR
NFVCNGQDDC SDGSDELDCT PPTCGAHEFQ CKSSTCIPIN WVCDDDADCS DQSDESLEQC
GRQPPPPVKC SRSEIQCGSG ECIHKRWRCD GDSDCKDGSD EINCPSRTCR PDQFKCEDGN
CIHGSRQCNG VRDCLDGTDE VNCKNVNQCS GSGKFKCRSG ECIDISKVCN QQQDCPDWSD
EPLRECNVNE CLVNNGGCSH ICRDLIIGYE CDCPAGFELI DRKTCGDIDE CQNPGICSQI
CINLKGGYKC ECSRGYQMDL ATGVCKAVGK EPCLIFTNRR DIRKIGLERK EYIQLVEQLR
NTVALDADIA EQRLFWADFS LKAIFSASLD TRDKVGKHIK TISNVHSPAA IAVDWVYKNI
YWTDSALKSI SVASLDGAKR KTLFNTDLRE PASIAVDPLS GFMYWSDWGE PAKIEKAGMN
GLGRQQLVTT EIQWPNGIAL DLIKSRLYWV DSKLHTLSSV DLNGQDRRIV LKSQEFLPHP
LALTIFEDRV YWIDGENEAI YGANKFTGSE LATLVNNLND AQDIIVYHEL VQPSGTNWCD
ETMNNGGCEY LCLPAPQMNE NSPKYACTCP TGYSLQEDGF RCKVSGAETT VAYIETKDTS
TTEKPPTVGP GPGGHNFSSA VSEVSSAKGT SAAWAVLPLL LLAVAAMAGG YFMWRNWQNK
NMKSMNFDNP VYLKTTEEDI NLDIGRHSSS VGHTYPAISV VSTDDDLA
//
