ID K7FT24_PELSI Unreviewed; 679 AA.
AC K7FT24;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011184.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01047537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01047543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000011184; -.
DR Ensembl; ENSPSIT00000011240.1; ENSPSIP00000011184.1; ENSPSIG00000010091.1.
DR eggNOG; KOG0939; Eukaryota.
DR GeneTree; ENSGT00940000166993; -.
DR HOGENOM; CLU_002173_11_0_1; -.
DR OMA; PAWDYTL; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 327..675
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 641
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 679 AA; 76295 MW; 2C896C2F726587D7 CRC64;
RWEQVVDLTY SLRLGAKPKA MEPDEAAVQK LRGVPPTWSY ECDEDLVRFL YDHLGKEDEN
LGSVKQYVES IDVSSYTVRG AGACRSALRC DAVAARPGFA PGREGCVLTV VTHVMVCLLS
TDTNNDGWVP AVGGGEPVSD CSLAASYIGD VCVLEDMTTH LPVIEIRIVE CREDGIDVRL
RGIKIKSSRQ RELGLSADTF QQASLVRYPR LEGTDPDLLY RRAMVIQRFV KLLDSVLHHI
VPAWDHTVGT FSWLKQIKQF LLLSERRTAL IAQCLKDSET SKPNFMPRLY INRRLAMEHR
DNPALEPSCK NAVFTQVHEG LKPSDKYEKP LDYRWPLRYD QWWECKFIAE GIIDQGGGFR
DSLADMSEEL CPSSAESPVP LPFFVRTSNQ GNSTGEARDM YIPNPSCKEF AKYEWIGQLM
GAALRGKEFL VSPAGGALAQ APRSRDLXWG KDSPAVDSVL VKLLEVMEVM DQETFEFKFG
KELTYTTVLS DQRMVELIPN GGSTVVRYED RQEFIRLVQK ARLEESKEQI AAMQAGLLRV
VPQAVLDLLT WQELEKKVCG DPEVTVDALK KLTRFEDFES SDTRVQYFWE ALSNFTNGEP
PLPYRHGPGC RVSPQPGPLA WLPKSLPSSE TTDALPESST CSSSLYLPNY ATAKVCEEKL
RYAAYNCVAI DTDMSPWEE
//
