ID K7FTU5_PELSI Unreviewed; 873 AA.
AC K7FTU5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN Name=NDST4 {ECO:0000313|Ensembl:ENSPSIP00000011455.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011455.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; AGCU01017390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006112816.1; XM_006112754.2.
DR RefSeq; XP_006112817.1; XM_006112755.2.
DR AlphaFoldDB; K7FTU5; -.
DR STRING; 13735.ENSPSIP00000011455; -.
DR Ensembl; ENSPSIT00000011512.1; ENSPSIP00000011455.1; ENSPSIG00000010254.1.
DR GeneID; 102456831; -.
DR KEGG; pss:102456831; -.
DR eggNOG; KOG3703; Eukaryota.
DR GeneTree; ENSGT00940000157168; -.
DR HOGENOM; CLU_011357_2_0_1; -.
DR OMA; ECTDIKI; -.
DR OrthoDB; 2913264at2759; -.
DR TreeFam; TF313193; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF45; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..506
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 596..845
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 605
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 703
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 808
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 824..828
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 809..819
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 873 AA; 100613 MW; 0CF88C9B7F60BBFE CRC64;
MNLIVKLRRS FRTLVILLTT FCLVSIVISA YYLYTGYKQE MTVVEATGEA ECEGLKHLPY
RSMELKTAKP MDPSNTDPTV LLFVESQYSQ LGQDIIAILE SSQFQYHMVI APGKGDIPPL
TDSGKGKYML VIYENILKYV SMDSWNRELL EKYCVEYSVS IIGFHKANEN SLPRTKLKGF
PLELYNNVAL KDCFVNSQSP LLHITKAPRV EKGPLPGEDW TVFLFNHSTY QPVLLTELQT
SKSIPASLPK AALYATVIQD LGLHDGIQRV LFGNNLTFWL HKLIFIDAIS FLSGKKLTLS
LNRYILVDID DIFVGKEGTR MNVQDVKALL ETQNLLRTQV ANFTFNLGFS GKFYHTGTEE
EDEGDDLLLG SVDEFWWFPH MWSHMQPHLF HNESSLVEQM ILNKDFALEH GIPTDMGYAV
APHHSGVYPV HVQLYEAWKK VWGIQVTSTE EYPHLKPARY RRGFIHNGIM VLPRQTCGLF
THTIFYKEYP GGPQDLDKSI RGGELFLTIL LNPISIFMTH LSNYGNDRLG LYTFLNLANF
VKSWTNLKLQ TLPPVQLAHK YFELFPEQKD PLWQNPCDDK RHRDIWSRDK TCDHLPKFLV
IGPQKTGTTA LYLFLLMHPS IISNLPSPKT FEEVQFFNGN NYHKGIDWYM DFFPTPSNVT
TDFLFEKSAN YFHSEEAPKR AASLIPKAKI ITILIDPSDR AYSWYQHQRS HEDPAALKFN
FYEVIASDHW APSELKTLQK RCLIPGWYAT HIERWLTHFP TSQLLIIDGQ QLRSDPATVM
DEVQKFLGVS PHYNYSEALT FDPQKGFWCQ LLEGGKTKCL GKSKGRKYPP MDQEARAFLS
NYYRDHNVEL SKLLHRLGQP LPYWLRQELQ KVR
//