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Database: UniProt
Entry: K7FTU5_PELSI
LinkDB: K7FTU5_PELSI
Original site: K7FTU5_PELSI 
ID   K7FTU5_PELSI            Unreviewed;       873 AA.
AC   K7FTU5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE            EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN   Name=NDST4 {ECO:0000313|Ensembl:ENSPSIP00000011455.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011455.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000011455.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005093}.
CC   -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004841}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC       {ECO:0000256|ARBA:ARBA00010420}.
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DR   EMBL; AGCU01017390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01017397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006112816.1; XM_006112754.2.
DR   RefSeq; XP_006112817.1; XM_006112755.2.
DR   AlphaFoldDB; K7FTU5; -.
DR   STRING; 13735.ENSPSIP00000011455; -.
DR   Ensembl; ENSPSIT00000011512.1; ENSPSIP00000011455.1; ENSPSIG00000010254.1.
DR   GeneID; 102456831; -.
DR   KEGG; pss:102456831; -.
DR   eggNOG; KOG3703; Eukaryota.
DR   GeneTree; ENSGT00940000157168; -.
DR   HOGENOM; CLU_011357_2_0_1; -.
DR   OMA; ECTDIKI; -.
DR   OrthoDB; 2913264at2759; -.
DR   TreeFam; TF313193; -.
DR   UniPathway; UPA00756; -.
DR   UniPathway; UPA00862; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605:SF45; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE 4; 1.
DR   PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          76..506
FT                   /note="Heparan sulphate-N-deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF12062"
FT   DOMAIN          596..845
FT                   /note="Sulfotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00685"
FT   ACT_SITE        605
FT                   /note="For sulfotransferase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT   BINDING         703
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT   BINDING         808
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT   BINDING         824..828
FT                   /ligand="3'-phosphoadenylyl sulfate"
FT                   /ligand_id="ChEBI:CHEBI:58339"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT   DISULFID        809..819
FT                   /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ   SEQUENCE   873 AA;  100613 MW;  0CF88C9B7F60BBFE CRC64;
     MNLIVKLRRS FRTLVILLTT FCLVSIVISA YYLYTGYKQE MTVVEATGEA ECEGLKHLPY
     RSMELKTAKP MDPSNTDPTV LLFVESQYSQ LGQDIIAILE SSQFQYHMVI APGKGDIPPL
     TDSGKGKYML VIYENILKYV SMDSWNRELL EKYCVEYSVS IIGFHKANEN SLPRTKLKGF
     PLELYNNVAL KDCFVNSQSP LLHITKAPRV EKGPLPGEDW TVFLFNHSTY QPVLLTELQT
     SKSIPASLPK AALYATVIQD LGLHDGIQRV LFGNNLTFWL HKLIFIDAIS FLSGKKLTLS
     LNRYILVDID DIFVGKEGTR MNVQDVKALL ETQNLLRTQV ANFTFNLGFS GKFYHTGTEE
     EDEGDDLLLG SVDEFWWFPH MWSHMQPHLF HNESSLVEQM ILNKDFALEH GIPTDMGYAV
     APHHSGVYPV HVQLYEAWKK VWGIQVTSTE EYPHLKPARY RRGFIHNGIM VLPRQTCGLF
     THTIFYKEYP GGPQDLDKSI RGGELFLTIL LNPISIFMTH LSNYGNDRLG LYTFLNLANF
     VKSWTNLKLQ TLPPVQLAHK YFELFPEQKD PLWQNPCDDK RHRDIWSRDK TCDHLPKFLV
     IGPQKTGTTA LYLFLLMHPS IISNLPSPKT FEEVQFFNGN NYHKGIDWYM DFFPTPSNVT
     TDFLFEKSAN YFHSEEAPKR AASLIPKAKI ITILIDPSDR AYSWYQHQRS HEDPAALKFN
     FYEVIASDHW APSELKTLQK RCLIPGWYAT HIERWLTHFP TSQLLIIDGQ QLRSDPATVM
     DEVQKFLGVS PHYNYSEALT FDPQKGFWCQ LLEGGKTKCL GKSKGRKYPP MDQEARAFLS
     NYYRDHNVEL SKLLHRLGQP LPYWLRQELQ KVR
//
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