ID K7FU90_PELSI Unreviewed; 740 AA.
AC K7FU90;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=TIE1 {ECO:0000313|Ensembl:ENSPSIP00000011600.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011600.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AGCU01012395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FU90; -.
DR STRING; 13735.ENSPSIP00000011600; -.
DR Ensembl; ENSPSIT00000011657.1; ENSPSIP00000011600.1; ENSPSIG00000010431.1.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000157693; -.
DR HOGENOM; CLU_008888_1_0_1; -.
DR OMA; AKVWWRL; -.
DR TreeFam; TF317568; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF341; TYROSINE-PROTEIN KINASE RECEPTOR TIE-1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 363..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 248..341
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 441..720
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 581
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 586
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 599
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 740 AA; 82641 MW; FD1C38B1B198FCE3 CRC64;
SMKAIMETEQ TTSEFLVPML TTADTGLWEC RVCTSRGQDS RRVKVNVKVP PVPLNPPRLL
AKQSRQLVVS PVDGFSGDGP IASIKLLYKP KDVTSPWSSI VVDNSENITL MNLRPVTAYL
VMVQLARPGD KGEGVAGPQA IMVTECQEPT AKPVIDGWSV EGKNTLHVNW NVPNNYEPAN
GFIVRLWDSA KVLVQEVNIT SMSVHSARIP YLEFNKEYGL EVFVYHCTRL GPPSDLCKVM
INSKGPSAPR SLHAEPLVDS AIQLTWQAPE YPNGGITKYI VELQQLGGAS EPQWVDTDSG
GETTKILRGL NASMWYQFRV RANSHVPGEW SEPVKAETLG DGNQRERGLS REGAVPRGLA
HELLLAIVGS VSVTCLTILL ALLALFLIKK NFFHRRRTFT YQSGSGEETI LQFNSGTLTL
TRRPQAQPEP LSYPILAWED ITFEDMIGEG NFGQVIRAMA GVSGLRLQRL LRCVSEFASE
NDHRDFAGEL EVLCKLGHHP NIINLLGACE NKGYLYIAIE YAPYGNLLDF LRKSRVLETD
PAFAKEHGTA STLTSQQLLQ FASDVAKGMQ YLSEKQFIHR DLAARNILVG ENLASKIADF
GLSRGEEVYV KKTMGRLPVR WMAIESLNYS VYTTKSDVWS FGVLLWEIVS LGGTPYCGMT
CAELYEKLPQ GYRMEKPRNC DDEVYEMMKQ CWRDRPYERP PFAQISMQLV RMLEARKAYV
NMALFENFTY AGIDATAEEA
//
