ID K7G100_PELSI Unreviewed; 359 AA.
AC K7G100;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Peroxisome assembly protein 12 {ECO:0000256|ARBA:ARBA00018980, ECO:0000256|PIRNR:PIRNR038074};
DE AltName: Full=Peroxin-12 {ECO:0000256|ARBA:ARBA00029692, ECO:0000256|PIRNR:PIRNR038074};
GN Name=PEX12 {ECO:0000313|Ensembl:ENSPSIP00000013960.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013960.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000013960.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of a retrotranslocation channel required for
CC peroxisome organization by mediating export of the PEX5 receptor from
CC peroxisomes to the cytosol, thereby promoting PEX5 recycling.
CC {ECO:0000256|PIRNR:PIRNR038074}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC membrane {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family.
CC {ECO:0000256|ARBA:ARBA00008704, ECO:0000256|PIRNR:PIRNR038074}.
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DR EMBL; AGCU01061162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006119669.1; XM_006119607.2.
DR AlphaFoldDB; K7G100; -.
DR STRING; 13735.ENSPSIP00000013960; -.
DR Ensembl; ENSPSIT00000014025.1; ENSPSIP00000013960.1; ENSPSIG00000012532.1.
DR GeneID; 102450152; -.
DR KEGG; pss:102450152; -.
DR CTD; 5193; -.
DR eggNOG; KOG0826; Eukaryota.
DR GeneTree; ENSGT00390000016209; -.
DR HOGENOM; CLU_031067_1_0_1; -.
DR OMA; RCPITGY; -.
DR OrthoDB; 65730at2759; -.
DR TreeFam; TF314511; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl.
DR GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR CDD; cd16451; mRING_PEX12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017375; PEX12.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12888:SF0; PEROXISOME ASSEMBLY PROTEIN 12; 1.
DR PANTHER; PTHR12888; PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038074};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140, ECO:0000256|PIRNR:PIRNR038074};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 27..267
FT /note="Pex N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04757"
SQ SEQUENCE 359 AA; 40176 MW; B2696E84EAC30CA3 CRC64;
MAERGAHLTA ASASDDTPSI FEVVAQDSLM SAVRPALQHV AKVLAESNPG CYGFLWHWFD
EIYALLDLLL QQHFLTKCSA SFSENFYGLK RIPLRDRKGL QQLASAGLPK KQHWKSLLLL
VLIPYLKTKL EKLVSSLREE DEYSIHPPSS AWKRFYRAFL AAYPFVNMAW EGWFLSQQLC
YILGKAQHHS PLLGLAGVRL VRLTAEDIQA LEQKLAEATA GQQVACSIKE QVQSTVKKAL
GGIALSLSTG LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDH GIRSPLLPAL
KTVCPLCHKI RANDTVLSTS GFVFCYRCVY TYVKSHQRCP ITGYATELQH LVKLYSPES
//
