ID K7G4F0_PELSI Unreviewed; 1079 AA.
AC K7G4F0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN Name=DLC1 {ECO:0000313|Ensembl:ENSPSIP00000015161.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015161.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015161.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; AGCU01021778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006113570.1; XM_006113508.1.
DR AlphaFoldDB; K7G4F0; -.
DR Ensembl; ENSPSIT00000015232.1; ENSPSIP00000015161.1; ENSPSIG00000013407.1.
DR GeneID; 102447887; -.
DR CTD; 10395; -.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_004367_0_0_1; -.
DR OrthoDB; 2883046at2759; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 634..840
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 870..1055
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 285..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 121458 MW; 1FB2D392AABB19E8 CRC64;
MILTQIEAKE ACDWLRAAGF PQYAQLYEDL LFPIDITLVK REHDFLDRDA IEALCRRLNT
LNKCAVMKLE ISPHRKRSED SDEDEPCAIS GKWTFQRDSK RWSRLEEFDV FPPKQDLNPS
SPGAPLLTNA ASHESVLTDF SERQEVVSIH STSSTSSHQV TLQSEATTTR TNSVVSVCSS
GNFIANNDSF SSLPSPKELS SFSFNMKANE KNARSKTKSL LKRMESLKIK SSHHGKNKAP
SKLGLIISGP ILKEGMDEDK LKQFNCVEIS TLNGNHINVP MVRKRSVSNS TQTSSSGSQS
ETSSAVSTPS PVTRTRSLSA YNKRVGMYLE GFDPFNQSTF SDVMEQNFKN RGSFAEDTVF
FIPEDHKPGT FPKALCNGNF SPSESNASVN WRTGSFHGHG HLSLRRENSA GSSKELSTGK
RRNSSSSMGS RLSIYDNVPG SILYSSTGDL ADLENEDLFP ELDDILCHVK GMQRLVNQWS
EKFSDEGDSD SALDSVSPCP SSPKQIHLDV DNDRATPSDL DSTGNSLTET EEPPGMQDRR
DSGVGASLTR SNRHRLRWHS FQSSHCPSLS SVSLQINSQS VAQMNLLQKY SLLKLTALLE
KYTPSNKHGF SWAVPKFMKR IKVPDYKDRN VFGVPLPINV QRTGQPLPQS IQQAMRYLRS
HCLDQVGLFR KSGVKSRIQA LRQMNESSTD CVNYEGQSAY DVADMLKQYF RDLPEPLMTN
KLSETFLQIY QYVPKDQRLQ AIKAAIMLLP DENREVLQIL LYFLSDVTAA VKENQMTPTN
LAVCLAPSLF HLNTLKRENS SPRVMQRKQS LGKPDQKDLN ENLAATQGLA HMIAECKKLF
QIPEEMSRCR NSYTEQDLRP LSLEELGRIN STEPSDYHCY LQDCMDDLLK EMKDKFKGWV
SCSTSEQADL AYKKVCEGPP LRLWKATIEV PAVPEDVLNR LLKEQHLWDE DLLDSKVIET
LDSQTDIYQY VQNSMAPHPA RDYVILRTWR TNLSKGACVL LASSVDHDRA PVVGIRVNVL
LSRYLIEPCG SGKSKLTYMC RIDLRGHMPE WYTKSFGHLC ASEVVKIRDS FSKKEVKSR
//
