ID K7G5U6_PELSI Unreviewed; 709 AA.
AC K7G5U6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Tripartite motif containing 28 {ECO:0000313|Ensembl:ENSPSIP00000015657.1};
GN Name=TRIM28 {ECO:0000313|Ensembl:ENSPSIP00000015657.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015657.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01152653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01152654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G5U6; -.
DR STRING; 13735.ENSPSIP00000015657; -.
DR Ensembl; ENSPSIT00000015731.1; ENSPSIP00000015657.1; ENSPSIG00000013810.1.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160527; -.
DR HOGENOM; CLU_005817_2_0_1; -.
DR OMA; DCKDEVP; -.
DR TreeFam; TF106455; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0070087; F:chromo shadow domain binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0035851; F:Krueppel-associated box domain binding; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0090309; P:positive regulation of DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR CDD; cd19846; Bbox1_TIF1b_C-VI; 1.
DR CDD; cd19829; Bbox2_TIF1b_C-VI; 1.
DR CDD; cd15623; PHD_TIF1beta; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037373; KAP1.
DR InterPro; IPR047059; TIF1b_Bbox1_Znf.
DR InterPro; IPR047058; TIF1b_Bbox2_Znf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR PANTHER; PTHR45915:SF9; TRIPARTITE MOTIF CONTAINING 28; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 2.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 36..83
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 92..133
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 486..533
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 675..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78514 MW; 90D05CD511E3FEDD CRC64;
AVVDCPVCKH QCYLKDIVEN YFLRDSGAEA ATDSKDANQC CTSCDDNAPA TSYCVECSEP
LCETCVEAHQ RVKYTKDHTV RATGPAKTKE GERTVYCSVH KHEPLVLFCD TCDTLTCRDC
QLNAHKDHQY QFLEDAVRNQ RKMLAALVKR LGDKHANLQK STKEVRTSIR QVTDVQKRVQ
VDVKMAILQI MKELNKRGKV LVSDAQKVTE GQQEKLERQH WAMTKLQRHQ EHILRFASWA
LESDNNTALL LSKKLIYFQL HRALKMIVDP VEPQGEMKFQ WDLNAWTKSA ETFGTIVSER
SGVPQSQPPP LQPPVQPARI LTAPVVKSGA GSTYPMDTQE EGFGDLADST EAHVSGMKRP
RSSDGNVMRK VPRVSLERLD LDLTVFPGNS NEDYNLIVIE RGAQQAATQP PGATQPGAIV
KEEQMEAAIE YPTEEPRDTK PIVLPQDALA AEGSMSRLIS PSGSGGSGLD VTASQNPEGG
TGAANAAHCR VCRKAGSVVM CNQCEQCYHL DCHLPVLQEI PSQEWKCLLC QELPEAGDED
GTHFSMSEDA SPKKLSPLEQ RKCERVLLEL LCHEPCRPLH RLSNATVSLG VEGQNTIDLT
LIRAKLQEKL SPPYGSSNEF AQDVWRMIKQ FNKLTEDKED VQSIIGLQRF FEAKWSAAFG
DRKFSSVLVE PIPLDEQRSE SSSSFTHRSS PSGSLGAAAT VSAGAGEEE
//
