ID K7G5Z2_PELSI Unreviewed; 339 AA.
AC K7G5Z2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015703.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015703.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AGCU01126177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01126178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G5Z2; -.
DR STRING; 13735.ENSPSIP00000015703; -.
DR Ensembl; ENSPSIT00000015777.1; ENSPSIP00000015703.1; ENSPSIG00000014032.1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT01100000263500; -.
DR HOGENOM; CLU_000384_33_10_1; -.
DR OMA; NIFEDEH; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF37; RIBONUCLEASE H; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..138
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 339 AA; 38632 MW; D409BEAEBA8E6961 CRC64;
MIIMVPSDLK VYESMSLRVT YLSTLDLTKG YWQIPLSAEA QATMAFATPF GLYQFRNMQF
GLHGAAATFQ RLMNRILRDH QDYAAAYIDD IIIFSESWEK HLEHLTEILE ALRQAGLTAN
PKKCQFGKTE ISYLGYTVGR GKLRPMVDKV QAVREYPTPT TKRKVRQFLG LAGYYRRFIA
NFASLAAPLT DLTRKGQPEK VKWTPACEAA FQELKKRLVC APVLAQPDFD KPFILQTDAS
EAGLGAVLTQ EEGGDGHPVL YLSRKLFPRE KGYATIEKEA LALKWAIDSL RYFLLGGKFT
VVTDHAPLQW MQNMKETNPR ILRWYLSLQP YQFQNALNT
//
