ID K7G948_PELSI Unreviewed; 560 AA.
AC K7G948;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Anaphylatoxin-like domain-containing protein {ECO:0000259|PROSITE:PS01178};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016809.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AGCU01098617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G948; -.
DR STRING; 13735.ENSPSIP00000016809; -.
DR Ensembl; ENSPSIT00000016886.1; ENSPSIP00000016809.1; ENSPSIG00000014972.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000154063; -.
DR HOGENOM; CLU_035611_0_0_1; -.
DR OMA; FRIMAYY; -.
DR TreeFam; TF335433; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006956; P:complement activation; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR Gene3D; 1.20.50.70; -; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR InterPro; IPR049466; C3_CUB1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21406; C3_CUB1; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PRINTS; PR00004; ANAPHYLATOXN.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 178..213
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
SQ SEQUENCE 560 AA; 62337 MW; B716506AC4C38904 CRC64;
MVTMSLLITP DLIPSFRIMA YYHVGYSEIV ADSVWIDVQD SCMGTLVVKG ATKADSKTQK
PASSMDIKVE GDAGALVGLV AVDKAVYVLN KKHKISQKKI WDTVEESDIG CTPGSGKDNM
GVFADAGLSL ATNIKISTPQ RTEPGCPQPA RRRRRAVQLI EYKANKAAAY QDRTLKKCCE
DGMYENPMGH SCEKRAGYIL DTAECRQAFL ECCNYIKTVR DERQRELHLE LARSDTDDGF
LQDESITSRS HFPESWLWHV WQLTQKPDKD GISSKTITIT LADSITTWEV LAVSISETKG
ICVADPYEIT VMKEFFIDLR LPYSVVRNEQ VEIRAVLYNY VRDKLKVRME LIHNPAFCSA
SSSKAKYSQI LEIPSMSSRA VPLVIVPLEL GLHDVEVKAS VWGVYVFDGV KKKLKVVPEG
TRVTKSVISV VLDPAAAGGE QVTKVKSLDI NDIVPNTEPE TKVSVNGNPV AHLLENSIDG
AKLGHLIMVP YGCGEQNMMS LTPTVIATHF LDNTNQWDRI GVDQRTEAIR LIRKGYTQQL
VYKKSDHSYT PYSKSTSSTW
//
