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Database: UniProt
Entry: K7G9Z3_PELSI
LinkDB: K7G9Z3_PELSI
Original site: K7G9Z3_PELSI 
ID   K7G9Z3_PELSI            Unreviewed;       324 AA.
AC   K7G9Z3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-NOV-2023, entry version 50.
DE   SubName: Full=Prostaglandin-E(2) 9-reductase-like {ECO:0000313|Ensembl:ENSPSIP00000017104.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017104.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000017104.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC       {ECO:0000256|ARBA:ARBA00007905}.
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DR   EMBL; AGCU01168592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7G9Z3; -.
DR   STRING; 13735.ENSPSIP00000017104; -.
DR   Ensembl; ENSPSIT00000017182.1; ENSPSIP00000017104.1; ENSPSIG00000015159.1.
DR   eggNOG; KOG1577; Eukaryota.
DR   GeneTree; ENSGT00940000153677; -.
DR   HOGENOM; CLU_023205_0_0_1; -.
DR   OMA; HLNPNGN; -.
DR   TreeFam; TF106492; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19108; AKR_AKR1C1-35; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044482; AKR1C.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732:SF165; ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3; 1.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT   DOMAIN          21..301
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        56
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         118
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            85
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   324 AA;  37223 MW;  AA129A4339AA9186 CRC64;
     MDFHNAMSMV MNDGHRIPVV GFGTYAPDTK YGHSLLNFIE FFIRRGCRHI DGAYFYENEE
     ELGRAIREKI ADGTVKREDI FYTGKLWSTF NAPEMVQSAL EKSLKTLQFD YIDLYIIHTP
     LSLKPGDDLL PVDGNGKLIF DNVDLCATWE AMEACKDAGL VKSIGVSNFN RRQLEMILNK
     PGLKYKPVCN QVECHPYLNQ GKLLEFCKSK NIVLVAFSAL GSHREEKWVV QSTPVLLEDP
     VLNKLAKKYN QSPVLVALRY QLQRGVVVLA KSFTRKHIED NIKVFDFHLT EEDMKAIDSL
     NQNLRYDLCA HFLDHPEYPF NDDY
//
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