ID K7GCP8_PELSI Unreviewed; 628 AA.
AC K7GCP8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Lymphocyte cytosolic protein 1 {ECO:0000313|Ensembl:ENSPSIP00000018059.1};
GN Name=LCP1 {ECO:0000313|Ensembl:ENSPSIP00000018059.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018059.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01051719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006118068.1; XM_006118006.2.
DR AlphaFoldDB; K7GCP8; -.
DR STRING; 13735.ENSPSIP00000018059; -.
DR Ensembl; ENSPSIT00000018143.1; ENSPSIP00000018059.1; ENSPSIG00000016060.1.
DR GeneID; 102448711; -.
DR KEGG; pss:102448711; -.
DR CTD; 3936; -.
DR eggNOG; KOG0046; Eukaryota.
DR GeneTree; ENSGT00950000183097; -.
DR HOGENOM; CLU_015284_2_0_1; -.
DR OMA; WQLMRKN; -.
DR OrthoDB; 5475188at2759; -.
DR TreeFam; TF300680; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0033157; P:regulation of intracellular protein transport; IEA:Ensembl.
DR GO; GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
DR CDD; cd21327; CH_PLS2_rpt2; 1.
DR CDD; cd21333; CH_PLS2_rpt4; 1.
DR CDD; cd21292; CH_PLS_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF35; PLASTIN-2; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..45
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 50..85
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 121..237
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 265..376
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 395..504
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 516..625
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 628 AA; 70146 MW; 09B6898A479CCE13 CRC64;
MASTAHISDD EMAELREAFN KIDMDGNGFI SSSELTELFK AANLPLPGYR IREITQNLMA
TGDQDNDGKI SFDEFISVFH GLKSTDVAKT FRKAINKKEG ICAIGGTSVQ SSVGTQHSYS
EEEKYAFVNW INKALENDPD CRHVLPMNPD TDDLFLAVGD GIVLCKMINF SVPDTIDERT
INKKKLTPFT IQENLNLALN SASAIGCHVV NIGAEDLKEG KPYLVLGLLW QVIKIGLFAD
IELSRNEALI ALLREGESLE DLMKLSPEEL LLRWANYHLE NAGCNKISNF STDIKDSKAY
YHLLNQVAPK GDEEGIPAIA IDMTGLREKD DIQRAECMLQ QAEKLGCRQF VTATDVVRGN
PKLNLAFIAN LFNRYPALHK PENQDIDWGS IEGETREERT FRNWMNSLGV SPRVNHLYSD
LSDALVIFQL YEKIKVPVDW NRVNKPPYPK LGGNMKKLEN CNYAVDLGKN QAKFSLVGIA
GQDLNEGNRT LTLALMWQLM RRYTLSILED IGGGQKVNDD IIVNWVNETL TEAGKSSVIS
SFKDSKISTS MPVLDLIDAI QPGSIKYDLL KTEDLNEEEK LNNAKYAISM ARKIGARVYA
LPEDLVEVKP KMVMTVFACL MGKGMKKV
//
