GenomeNet

Database: UniProt
Entry: K7GIG5_PELSI
LinkDB: K7GIG5_PELSI
Original site: K7GIG5_PELSI 
ID   K7GIG5_PELSI            Unreviewed;       814 AA.
AC   K7GIG5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSPSIP00000020076};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
OC   Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000020076, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Ensembl:ENSPSIP00000020076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17381049; DOI=10.1080/10425170600760091;
RA   Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
RT   "The complete mitochondrial genome of the Korean soft-shelled turtle
RT   Pelodiscus sinensis (Testudines, Trionychidae).";
RL   DNA Seq. 17:471-483(2006).
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000020076}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPSIP00000020076}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGCU01061891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01061899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 13735.ENSPSIP00000020076; -.
DR   Ensembl; ENSPSIT00000020170; ENSPSIP00000020076; ENSPSIG00000017725.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007267};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    374    399       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    420    437       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    513    535       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    606    625       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    742    766       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       58     92       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   814 AA;  94063 MW;  D53F870CC26EC8EC CRC64;
     LPQLNPSVSV FQRKFVGEVK KCEEMERILG FLVQEIKKAD IPLPEGDTAP AAPQLKHILE
     IQEQLQKLET ELREVTKNKE KLKKNLLELT EYTHMLRVTQ AFVKRAVEYE SCLHTNYEEF
     PSLENDPLMD YTCMHRLGAK LGFVSGLVHQ AKIEAFEKML WRVCKGYTIL TYAELDDCLE
     DPDTGEITKW FVFLISFWGE QIGQKVKKIC DCYHCHVYPY PNTTEERREV IEGLNVRIQD
     LHVVLRKTED YLRQVLCKAS ESIYTWVIQV KKMKAIYHVL NQCSFDVTNK CLIAEVWCPE
     ADLQTLRRAL EEGSRKSGAA VSSFMNTIPT TETPPTLIRT NKFTSGFQNI VDAYGVGNYR
     EVNPALYTII TFPFLFAVMF GDFGHGLLMF IFALMMVLYE NHPRLQRSQD EIMKTFFEGR
     YIILLMGLFS VYTGLIYNDC FSKSLNIFGS GWNILAMFEQ RIWHLDDLKS NRYLSLDPNI
     TGVFSGIYPL GIDPIWNLAN NRLSFLNSFK MKMSVIFGVT HMTFGVVLGV FNHLYFRKKH
     NIYLVFLPEL FFMLCIFGYL VFMIIFKWLA YNAENSRTAP SILIQFITMF LFPTSGKDTL
     YTGQVILQRF LFIIALLSVP VMLFGKPLYL YWLHNGGRGI GIYRNGYRLV RKESEEELSL
     LRAHDVEEGS SPSESRHQEG TVEEFNFADV FMNQTIHTIE YCLGCISNTA SYLRLWALSL
     AHAQLSEVLW AMIMRVGLRV DAAYGILLLV PVLAFFAVLT VFILLVMEGL SAFLHAVRLH
     WVEFQNKFYT GGGYKFTPFS FKHIFLHFNK DDIA
//
DBGET integrated database retrieval system