ID K7GJ70_PELSI Unreviewed; 724 AA.
AC K7GJ70;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSPSIP00000020331.1};
GN Name=AGAP1 {ECO:0000313|Ensembl:ENSPSIP00000020331.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000020331.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000020331.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR EMBL; AGCU01115627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GJ70; -.
DR Ensembl; ENSPSIT00000020427.1; ENSPSIP00000020331.1; ENSPSIG00000017950.1.
DR GeneTree; ENSGT00940000154793; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08853; ArfGap_AGAP2; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF1; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 212..455
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 476..596
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 635..667
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 133..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 79882 MW; 66DED5645173290C CRC64;
MWVDAVIFVF SLEDEISFQT VYHYYSRMAN YRNTSEIPMV LVGTQDAISS NNPRVIDDGR
ARKLSNDLKR CTYYETCATY GLNVERVFQD VAQKIVATRK KQQLSIGPCK SLPNSPSHSS
VCSAQVSAVH ITQTSNGGGS LSDYSSSVPS TPSTSQKELR IDVPPTANTP TPVRKQSKRR
SNLFTSRKGS DPDKEKKVLE SRTDSIGSGR AIPMKQGVLL KRSGKSLNKE WKKKYVTLCD
NGVLTYHPSL HDYMQNVHGK EIDLLRTTVK VPGKRPPRAT SACAPISSPK TNGMSKDMSS
LHISPNSGNV TTSTSVSQMA SGISLVSFNS RPDGMHQRSY SVSSADQWSE ATVIANSGIS
SDTGLGDSVC SSPSISSTTS PKLDPPPSPH ANRKKHRRKK STSNFKADGV SGAAEEQEEN
FEFIIVSLTG QTWHFEATTY EERDAWVQAI ESQILASLQS CESSKNKSRL TSQNEAMALQ
SIRNIRGNSH CVDCEAQDPD WASLNLGALM CIECSGIHRN LGTHLSRVRS LDLDDWPIEL
IKVMSSIGNE LANSVWEESS QGHMKPSLDS TREEKERWIR AKYEQKLFLA PLQWLEVSLG
QHLLRATAEE DLRTVILLLA HGTREEVNET CGDGDGRTAL HLACRKGNVV LVQLLIWYGV
DVMARDAQGN TALAYARQAT SQECIDVLLQ YGCPDERFVL MATPNLSRKN NNRNNSSGRM
PTII
//
