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Database: UniProt
Entry: K7H5B4_CAEJA
LinkDB: K7H5B4_CAEJA
Original site: K7H5B4_CAEJA 
ID   K7H5B4_CAEJA            Unreviewed;       993 AA.
AC   K7H5B4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   10-MAY-2017, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Caenorhabditis japonica.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=281687 {ECO:0000313|EnsemblMetazoa:CJA13291a, ECO:0000313|Proteomes:UP000005237};
RN   [1] {ECO:0000313|EnsemblMetazoa:CJA13291a}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DF5081 {ECO:0000313|EnsemblMetazoa:CJA13291a};
RG   Caenorhabditis japonica Sequencing Consortium;
RA   Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CJA13291a}
RP   IDENTIFICATION.
RC   STRAIN=DF5081 {ECO:0000313|EnsemblMetazoa:CJA13291a};
RG   EnsemblMetazoa;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 281687.CJA13291a; -.
DR   EnsemblMetazoa; CJA13291a; CJA13291a; WBGene00132495.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; K7H5B4; -.
DR   OrthoDB; EOG091G0QTE; -.
DR   Proteomes; UP000005237; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:EnsemblMetazoa.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0040011; P:locomotion; IEA:EnsemblMetazoa.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0001666; P:response to hypoxia; IEA:EnsemblMetazoa.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005237};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005237};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    396    420       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    553       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    594       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    854    876       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    934    956       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      106    140       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   993 AA;  112091 MW;  22A3F54B5214AD22 CRC64;
     MGDYVTPGEE PPQPGIYRSE QMCLAQLYLQ SDASYQCVAE LGELGLVQFR DLNPDVSSFQ
     RKYVNEVRRC DEMERKLRFL EREIKKDQIP MLDTGENPDA PLPREMIDLE ATFEKLESEL
     REVNKNEETL KKNFSELTEL KHILRKTQTF FEEKKGTTTT TTTTTTFASV RPSVRHQSVS
     PFHTYPSRSN AACAVSLIVA ASSSMSPPMS ISGRSSSADA NRKILRKCSI FSSRFRATLY
     PCPDTPQERR EMSIGVMTRI EDLKTVLGQT QDHRHRVLVA ASKNVRMWLT KVRKIKSIYH
     TLNLFNIDVT QKCLIAEVWC PIAELDRIKM ALKRGTDESG SQVPSILNRM ESNEAPPTYN
     KTNKFTKGFQ NIVDAYGIAT YREINPAPYT MISFPFLFAV MFGDMGHGCI MFLAALFFIL
     KEKQLEAARI RDEIFQTFFG GRYVIFLMGV FSIYTGFMYN DVFSKSLNAF GSSWKNSIPE
     SIIDSYLEDP EKAEAQLILP PESSYDGSPY PIGVDPIWNL AEGNKLSFLN SMKMKMSVLF
     GIAQMTFGVL LSYKNHTYFK SDLDIKFMFI PQMIFLSSIF IYLCIQILAK WLFFGAAAET
     VLGYAYPGSN CAPSLLIGLI NMFMMKSRNA GFVDEHGNVY SQCHLSTWYP GQSTVEKILV
     IMALVQVPVM LFAKPYFLHQ REKRANRYST ISDPHQSVRA DINQDDAEVV HAPEQTPKPS
     GGGHGHGDGP LDMADVMVYQ AIHTIEFVLG CVSHTASYLR LWALSLAHAQ LSDVLWTMVF
     RNAFVMDGYA GAVATYVXXX XXXXXXXXXX XXXXCALSKK NFDRGPVICR YKKLCIAGCV
     LQEGSYQTAT WQLFGGYLAA TWRLFGGYLA AIWRLFGGYL AANWQLIGGY LAAIWRLFGG
     YLAAIWRLFG GYLAAIWRLF GGYLAAVWQL SGSYLAAVWQ LSGSISYQFY FVRVLFRTSS
     ISYEFYFVRV LFRTSSIPCS SIPCSSISFS SIT
//
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