GenomeNet

Database: UniProt
Entry: K7ITW6_NASVI
LinkDB: K7ITW6_NASVI
Original site: K7ITW6_NASVI 
ID   K7ITW6_NASVI            Unreviewed;       850 AA.
AC   K7ITW6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-SEP-2017, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Terebrantes;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV12522-PA, ECO:0000313|Proteomes:UP000002358};
RN   [1] {ECO:0000313|EnsemblMetazoa:NV12522-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV12522-PA};
RX   PubMed=20075255; DOI=10.1126/science.1178028;
RG   Nasonia Genome Working Group;
RA   Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J.,
RA   Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O.,
RA   Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G.,
RA   Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C.,
RA   Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M.,
RA   Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K.,
RA   Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M.,
RA   Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M.,
RA   Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P.,
RA   Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G.,
RA   Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B.,
RA   Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D.,
RA   Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G.,
RA   Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D.,
RA   Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M.,
RA   Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y.,
RA   Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L.,
RA   Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R.,
RA   Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D.,
RA   Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D.,
RA   Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V.,
RA   Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O.,
RA   Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R.,
RA   Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T.,
RA   Reid J.G., Riddle M., Robertson H.M., Romero-Severson J.,
RA   Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T.,
RA   Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L.,
RA   Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A.,
RA   Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A.,
RA   Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W.,
RA   Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M.,
RA   Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N.,
RA   Zhang L., Gibbs R.A.;
RT   "Functional and evolutionary insights from the genomes of three
RT   parasitoid Nasonia species.";
RL   Science 327:343-348(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:NV12522-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 7425.NV12522-PA; -.
DR   EnsemblMetazoa; NV12522-RA; NV12522-PA; NV12522.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; K7ITW6; -.
DR   PhylomeDB; K7ITW6; -.
DR   Proteomes; UP000002358; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002358};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002358};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    434       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    651    670       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    803       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       95    129       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   850 AA;  97339 MW;  0CE1FA73E862B3A2 CRC64;
     MGTMFRSEEM ALCQLYIQPE AVYLTVSELG EAGIVQFRDL NEKVTHFQRR FVNEVRRCDD
     LERKLRYIEA EVKKDEVPIV EDLKDLPRAP NPRQMIDLEA RVEKSEGDIR ELSQNAVNLK
     SDYLELIELR HVLEKNHVFF AENQGLLLLL YQQDEANDSI RPLISDENQM QTSRGRLEFV
     AGVISRERMP AFERMLWRIS RGNVFLRQAN LDEQLEDPTT GAAIYKTVFV AFFQGEELKS
     RIKKVCIGFH ASLYPIPNSH AERMEMVKGV RTRLEDLNLV LNQTNDHRQR VLRSVAKELP
     LWTIMVHKMK AIYHTMNLFS IDISKKCLIG ECWAPISDLA ALQDCLTEGS RLCGNSIPSF
     LNVIETNDNP PTFNRSTKYT RAFQILIDSY GVSSYREANP ALYAIVTFPF LFAVMFGDVG
     HGLIMFLFGL YMVLQEKKFM AQKSSNEIWN IFFGGRYVIL LMGLYSVYTG FVYNDLFSKS
     MNIFGSSWEI RKVAFPKFSN VTEKKQHLLF PKKSYIDHPY PIGVDPVWAL AENKIIFLNS
     FKMKLSIIFG VVHMIFGVCM SAVNMVHLRK YASLFVEFLP QLLLLLVLFA YLAFLMFLKW
     VLYSGLIKGR YSESCAPSIL ITFINMMLFG SSDPEEPCEE FMFPGHATMQ LVFLGIALVC
     IPVLLFGKPL HFLFTHRKKG VVHANGSASQ NISNGVAGPS GSKVSHEEHE EFGEVMIQQA
     IHTIEYVLST ISHTASYLRL WALSLAHAQL SEVLWNMVMG KILSFPLMTM GVEVEIEMAI
     KGVAMFLAFG AWSVFTLAIL VLMEGLSAFL HTLRLHWVEF MSKFYKGEGY LFQPYYFKTI
     LDSEDCPDQD
//
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