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Database: UniProt
Entry: K7IYB3_NASVI
LinkDB: K7IYB3_NASVI
Original site: K7IYB3_NASVI 
ID   K7IYB3_NASVI            Unreviewed;       829 AA.
AC   K7IYB3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-JUL-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC100116803 {ECO:0000313|EnsemblMetazoa:NV14086-PD};
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Terebrantes;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV14086-PD, ECO:0000313|Proteomes:UP000002358};
RN   [1] {ECO:0000313|EnsemblMetazoa:NV14086-PD}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV14086-PD};
RX   PubMed=20075255; DOI=10.1126/science.1178028;
RG   Nasonia Genome Working Group;
RA   Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J.,
RA   Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O.,
RA   Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G.,
RA   Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C.,
RA   Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M.,
RA   Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K.,
RA   Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M.,
RA   Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M.,
RA   Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P.,
RA   Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G.,
RA   Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B.,
RA   Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D.,
RA   Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G.,
RA   Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D.,
RA   Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M.,
RA   Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y.,
RA   Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L.,
RA   Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R.,
RA   Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D.,
RA   Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D.,
RA   Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V.,
RA   Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O.,
RA   Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R.,
RA   Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T.,
RA   Reid J.G., Riddle M., Robertson H.M., Romero-Severson J.,
RA   Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T.,
RA   Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L.,
RA   Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A.,
RA   Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A.,
RA   Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W.,
RA   Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M.,
RA   Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N.,
RA   Zhang L., Gibbs R.A.;
RT   "Functional and evolutionary insights from the genomes of three
RT   parasitoid Nasonia species.";
RL   Science 327:343-348(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:NV14086-PD}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EnsemblMetazoa; NV14086-RD; NV14086-PD; NV14086.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   PhylomeDB; K7IYB3; -.
DR   Proteomes; UP000002358; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002358};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002358};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    397    420       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    440    465       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    534    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    586       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    754    779       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   829 AA;  95599 MW;  BBAF56B799041ECA CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGENPEAPQ PREMIDLEAT FEKLENELRE VNLNAEALKR
     NFLELTELKH ILRKTQVFFD EMADPSREEE QVTLLGEEGL RAGGQALKLG FVAGVILRER
     IPAFERMLWR ACRGNVFLRQ AEIETPLEDP STGDQVHKSV FIIFFQGDQL KTRVKKICEG
     FRATLYPCPE APADRREMAM GVMTRIEDLN TVLGQTQDHR HRVLVAAAKN IKNWFIKVRK
     IKAIYHTLNL FNLDVTQKCL IAECWVPVLD IETIQLALRR GTERSGSSVP PILNRMETFE
     DPPTYNRTNK FTKGFQALID AYGVASYREM NPAPYTIITF PFLFAIMFGD FGHGLIMFLF
     GGWMVLKEKP LAAQKSDNEI WNIFFGGRYI IFLMGIFSMY TGFIYNDIFS KSLNVFGTYW
     TVTNITTDNV MNIKSFQLDP TWSYIQHPYP IGMDPVWQLA ENKIIFLNSY KMKISIIFGV
     IHMLFGVIVG LFNHLYFKRR INIICEFIPQ IIFLIFLFFY LTLLMFIKWV KYAAYSSYCA
     PSVLITFINM VLFKAPTQLP NCDEYMYGGE HFFERFLVLV GLLCIPWMLL AKPFMMMKER
     KKKHMQLNTH GTENGDIDGG VMQSQGGQMQ GGHKEEEEMS EVFIHQGIHT IEYVLGSVSH
     TASYLRLWAL SLAHAQLSEV LWNMVMKNGL TQEGWYGGIV LWAIFAFWAV LTVGILVLME
     GLSAFLHTLR LHWVEFQSKF YLGQGYSFTP FSFEIILETA QSATETVTD
//
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