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Database: UniProt
Entry: K7IYB5_NASVI
LinkDB: K7IYB5_NASVI
Original site: K7IYB5_NASVI 
ID   K7IYB5_NASVI            Unreviewed;       844 AA.
AC   K7IYB5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC100116803 {ECO:0000313|EnsemblMetazoa:NV14086-PF};
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Terebrantes;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV14086-PF, ECO:0000313|Proteomes:UP000002358};
RN   [1] {ECO:0000313|EnsemblMetazoa:NV14086-PF}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV14086-PF};
RX   PubMed=20075255; DOI=10.1126/science.1178028;
RG   Nasonia Genome Working Group;
RA   Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J.,
RA   Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O.,
RA   Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G.,
RA   Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C.,
RA   Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M.,
RA   Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K.,
RA   Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M.,
RA   Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M.,
RA   Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P.,
RA   Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G.,
RA   Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B.,
RA   Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D.,
RA   Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G.,
RA   Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D.,
RA   Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M.,
RA   Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y.,
RA   Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L.,
RA   Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R.,
RA   Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D.,
RA   Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D.,
RA   Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V.,
RA   Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O.,
RA   Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R.,
RA   Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T.,
RA   Reid J.G., Riddle M., Robertson H.M., Romero-Severson J.,
RA   Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T.,
RA   Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L.,
RA   Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A.,
RA   Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A.,
RA   Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W.,
RA   Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M.,
RA   Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N.,
RA   Zhang L., Gibbs R.A.;
RT   "Functional and evolutionary insights from the genomes of three
RT   parasitoid Nasonia species.";
RL   Science 327:343-348(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:NV14086-PF}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_001607818.1; XM_001607768.4.
DR   EnsemblMetazoa; NV14086-RF; NV14086-PF; NV14086.
DR   GeneID; 100116803; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   PhylomeDB; K7IYB5; -.
DR   Proteomes; UP000002358; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002358};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002358};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    470       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    560       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    651    670       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    769    794       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   844 AA;  97294 MW;  FF2143C22FB4EA60 CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGENPEAPQ PREMIDLEAT FEKLENELRE VNLNAEALKR
     NFLELTELKH ILRKTQVFFD EQEHAGLNST ESMTRALISD DNIARQSALG PVQLGFVAGV
     ILRERIPAFE RMLWRACRGN VFLRQAEIET PLEDPSTGDQ VHKSVFIIFF QGDQLKTRVK
     KICEGFRATL YPCPEAPADR REMAMGVMTR IEDLNTVLGQ TQDHRHRVLV AAAKNIKNWF
     IKVRKIKAIY HTLNLFNLDV TQKCLIAECW VPVLDIETIQ LALRRGTERS GSSVPPILNR
     METFEDPPTY NRTNKFTKGF QALIDAYGVA SYREMNPAPY TIITFPFLFA IMFGDFGHGL
     IMFLFGGWMV LKEKPLAAQK SDNEIWNIFF GGRYIIFLMG IFSMYTGFIY NDIFSKSLNV
     FGTYWTVTNI TTDNVMNIKS FQLDPTWSYI QHPYPIGMDP VWQLAENKII FLNSYKMKIS
     IIFGVIHMLF GVIVGLFNHL YFKRRINIIC EFIPQIIFLI FLFFYLTLLM FIKWVKYAAY
     HPIYNTDVKT SSYCAPSVLI TFINMVLFKA PTQLPNCDEY MYGGEHFFER FLVLVGLLCI
     PWMLLAKPFM MMKERKKKHM QLNTHGTENG DIDGGVMQSQ GGQMQGGHKE EEEMSEVFIH
     QGIHTIEYVL GSVSHTASYL RLWALSLAHA QLSEVLWNMV MKNGLTQEGW YGGIVLWAIF
     AFWAVLTVGI LVLMEGLSAF LHTLRLHWVE FQSKFYLGQG YSFTPFSFEI ILETAQSATE
     TVTD
//
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