ID K7KLG8_SOYBN Unreviewed; 1099 AA.
AC K7KLG8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=100781715 {ECO:0000313|EnsemblPlants:KRH64048};
GN ORFNames=GLYMA_04G213400 {ECO:0000313|EMBL:KRH64048.1};
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847 {ECO:0000313|EMBL:KRH64048.1};
RN [1] {ECO:0000313|EMBL:KRH64048.1, ECO:0000313|EnsemblPlants:KRH64048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Williams 82 {ECO:0000313|EnsemblPlants:KRH64048};
RC TISSUE=Callus {ECO:0000313|EMBL:KRH64048.1};
RX PubMed=20075913; DOI=10.1038/nature08670;
RA Schmutz J., Cannon S.B., Schlueter J., Ma J., Mitros T., Nelson W.,
RA Hyten D.L., Song Q., Thelen J.J., Cheng J., Xu D., Hellsten U., May G.D.,
RA Yu Y., Sakurai T., Umezawa T., Bhattacharyya M.K., Sandhu D.,
RA Valliyodan B., Lindquist E., Peto M., Grant D., Shu S., Goodstein D.,
RA Barry K., Futrell-Griggs M., Abernathy B., Du J., Tian Z., Zhu L., Gill N.,
RA Joshi T., Libault M., Sethuraman A., Zhang X.-C., Shinozaki K.,
RA Nguyen H.T., Wing R.A., Cregan P., Specht J., Grimwood J., Rokhsar D.,
RA Stacey G., Shoemaker R.C., Jackson S.A.;
RT "Genome sequence of the palaeopolyploid soybean.";
RL Nature 463:178-183(2010).
RN [2] {ECO:0000313|EnsemblPlants:KRH64048}
RP IDENTIFICATION.
RC STRAIN=Williams 82 {ECO:0000313|EnsemblPlants:KRH64048};
RG EnsemblPlants;
RL Submitted (FEB-2018) to UniProtKB.
RN [3] {ECO:0000313|EMBL:KRH64048.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Callus {ECO:0000313|EMBL:KRH64048.1};
RA Schmutz J., Cannon S., Schlueter J., Ma J., Mitros T., Nelson W., Hyten D.,
RA Song Q., Thelen J., Cheng J., Xu D., Hellsten U., May G., Yu Y.,
RA Sakurai T., Umezawa T., Bhattacharyya M., Sandhu D., Valliyodan B.,
RA Lindquist E., Peto M., Grant D., Shu S., Goodstein D., Barry K.,
RA Futrell-Griggs M., Abernathy B., Du J., Tian Z., Zhu L., Gill N., Joshi T.,
RA Libault M., Sethuraman A., Zhang X., Shinozaki K., Nguyen H., Wing R.,
RA Cregan P., Specht J., Grimwood J., Rokhsar D., Stacey G., Shoemaker R.,
RA Jackson S.;
RT "WGS assembly of Glycine max.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; CM000837; KRH64048.1; -; Genomic_DNA.
DR AlphaFoldDB; K7KLG8; -.
DR SMR; K7KLG8; -.
DR STRING; 3847.K7KLG8; -.
DR PaxDb; 3847-GLYMA04G39150-2; -.
DR EnsemblPlants; KRH64048; KRH64048; GLYMA_04G213400.
DR Gramene; KRH64048; KRH64048; GLYMA_04G213400.
DR eggNOG; KOG0903; Eukaryota.
DR InParanoid; K7KLG8; -.
DR Proteomes; UP000008827; Chromosome 4.
DR ExpressionAtlas; K7KLG8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000008827};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..140
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 816..1084
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 179..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 124845 MW; B1EF2E35FF8C8987 CRC64;
MVRLLGLSRG EVDEPREIAS KSNLTSESSE NGWLIRFFDS SFFCEWIAVS YLYKHDHAGV
RDYLCNRMYT LPLQGIESYL FQVCYMMIHK PSPSLDKFVI DICSKSLKIA LKVQWFLLAE
LEDSDDNEGI SRVQEKCQIA ATLMGEWQPL IWPQSTPASP GGKNQVLNKI LSSKQRLLSL
TSSPPPHRSL SFSPSSGNNL QEDGSPQSPE ENKLFKKFMP GPKVRDALLF RKSVAKDDDD
SEKDGFLKRL LRDSKGDDEF GQKIRDAFLF RKSSEKYDED SEKDNILKRL LRDGRGDDLE
SEKDGFFRRL LRDSKAEDED LASSSEGFFK RLFRDSKNDS DDKTNTKTME DEEKEGFFRK
LFREKFEDKK DGNDEGDIAN SEEKCAKPAE EDEKEGFFRK FFKDKFDDKK DTNDKIDDGT
TNVEEEEPSD FSLFKRIFRV HPEDGKSSSA NENNGGLFES SPGTENFFRK LFRDRDRSIE
DSELLGSKKQ KEQRHQKTGT KPPLPINPSQ FRKGAYHESL DFVLTLCDTS FGLVDVFPVE
DRKHALHESL AEINIHLTES QNTGGVCFPL GKGMYCVLHI PEDEAVLLNS REKAPYLICV
EVLRCEMPSH SKETSSSQKL SKGGIPLANG DAFLQKPPPW AYPLWTAQEA YRNSNDRMSR
LTAEAIDQAM THASDTKVKF VSVNLSVEAQ LHGRPERTEA DLCGGYRYPA STYRDGIQEV
ARSGHDSNME WVRVVLKADP GVRMEDIEDQ APRRRKEHRR VPSTVAIEEV KAAAAKGEAP
LGLPLKGAGQ DSSDAPPRAN GIIPKASDAL SGELWEVKKE RIRKASIHGN LPGWDLRSVI
VKSGDDCRQE HLAVQLISHF YDIFQEAGLP LWLRPYEVLC TSSYTALIET IPDTASVHSI
KSRYPNISSL REFFIAKYQE NSPSFKLAQR NFVESMAGYS LVCYLLQVKD RHNGNLLMDE
EGHIIHIDFG FMLSNSPGGV NFESAPFKLT RELLEVMDSD AEGIPSEFFD YFKVLCIQGF
LTCRKHAERI ILLVEMLQDS GFPCFKGGPR TIQNLRKRFH LNLTEEQCVS LVLSLISSSL
DAWRTRQYDY YQRVLNGIL
//
