ID K7NAJ2_FELCA Unreviewed; 506 AA.
AC K7NAJ2;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=aromatase {ECO:0000256|ARBA:ARBA00038885};
DE EC=1.14.14.14 {ECO:0000256|ARBA:ARBA00038885};
DE AltName: Full=Cytochrome P-450AROM {ECO:0000256|ARBA:ARBA00043174};
DE AltName: Full=Estrogen synthase {ECO:0000256|ARBA:ARBA00042499};
GN Name=CYP19A1 {ECO:0000313|EMBL:ADU04376.1,
GN ECO:0000313|Ensembl:ENSFCAP00000018380.1,
GN ECO:0000313|VGNC:VGNC:103332};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|EMBL:ADU04376.1};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018380.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018380.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|EMBL:ADU04376.1}
RP NUCLEOTIDE SEQUENCE.
RA Braun B.C., Jewgenow K.;
RT "Characterization of Felis catus and Lynx pardinus cytochrome P450
RT aromatase expression in the female reproductive system.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018380.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018380.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSFCAP00000018380.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018380.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AANG04001761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU306147; ADU04376.1; -; mRNA.
DR RefSeq; XP_006932587.1; XM_006932525.2.
DR RefSeq; XP_019687983.1; XM_019832424.1.
DR STRING; 9685.ENSFCAP00000018380; -.
DR PaxDb; 9685-ENSFCAP00000018380; -.
DR Ensembl; ENSFCAT00000024591.4; ENSFCAP00000018380.1; ENSFCAG00000023859.4.
DR VGNC; VGNC:103332; CYP19A1.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00840000129915; -.
DR HOGENOM; CLU_041874_0_0_1; -.
DR OMA; PGLQCIG; -.
DR OrthoDB; 5385594at2759; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000023859; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070330; F:aromatase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006710; P:androgen catabolic process; IEA:Ensembl.
DR GO; GO:0030540; P:female genitalia development; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IEA:Ensembl.
DR GO; GO:0010760; P:negative regulation of macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:2000866; P:positive regulation of estradiol secretion; IEA:Ensembl.
DR GO; GO:0060736; P:prostate gland growth; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR GO; GO:0061370; P:testosterone biosynthetic process; IEA:Ensembl.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR CDD; cd20616; CYP19A1; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF43; AROMATASE; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461}; Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461,
KW ECO:0000313|EMBL:ADU04376.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 506 AA; 58306 MW; 5D6FCC3749A68E9E CRC64;
MVLEMLNPMH YNITSMMPEV MPVATMPILL LTGFLLLVWN YEDTSSIPGP GYCMGIGPLI
SHCRFLWMGI GSACNYYNKM YGEFMRVWIC GEETLIISKS SSMFHVMKHS HYSSRFGSKL
GLQCIGMHEN GIIFNNNPTL WKAVRPFFTK ALSGPGLVRM VTICVESVIT HLDRLEEVTN
ELGYIDVLTL MRRIMLDTSN MLFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL
YRKYEKSVKD LKDAMEILIE EKRHRISTAE KLEDCMDFAT ELIFAEKRGD LTKENVNQCI
LEMLIAAPDT MSVSVFFMLF LIAKHPKVEE AIMKEIQTVV GEREIRIDDM QKLKVVENFI
YESMRYQPVV NLVMRKALQD DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK
NVPYRYFQPF GFGPRSCAGK YIAMVMLKVI LVTLLRRFHV QTLQGECIEN MQKKHGLSLH
PDETGNLLEM VFTPRHSEKC LNTKEG
//