ID   K7U1Y7_MAIZE            Unreviewed;       337 AA.
AC   K7U1Y7; A0A3L6G7D2;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Glyoxylate/hydroxypyruvate reductase HPR3 {ECO:0000313|EMBL:AQK42302.1};
GN   ORFNames=ZEAMMB73_Zm00001d024907 {ECO:0000313|EMBL:AQK42302.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:AQK42302.1};
RN   [1] {ECO:0000313|EMBL:AQK42302.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Seedling {ECO:0000313|EMBL:AQK42302.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CM000786; AQK42302.1; -; Genomic_DNA.
DR   AlphaFoldDB; K7U1Y7; -.
DR   SMR; K7U1Y7; -.
DR   STRING; 4577.K7U1Y7; -.
DR   PaxDb; 4577-GRMZM2G174773_P02; -.
DR   eggNOG; KOG0069; Eukaryota.
DR   HOGENOM; CLU_019796_1_2_1; -.
DR   InParanoid; K7U1Y7; -.
DR   OMA; VIVTAHQ; -.
DR   ExpressionAtlas; K7U1Y7; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   CDD; cd12156; HPPR; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996:SF246; -; 1.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Pyruvate {ECO:0000313|EMBL:AQK42302.1}.
FT   DOMAIN          64..332
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          127..301
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   337 AA;  35576 MW;  84D4271FE9629E60 CRC64;
     MTIPGGVQRI LPVPAVLFIR RPGAPFGNAM HERFRVLELP SPASSEQAAA FLAAAAAEPD
     PPRAAVVMGG GAVRADAAFL DAVPSVRCLV STAAGVDHID LAECARRGVA VANSGTVYSA
     DVADHAVGML IDVLRRVSAA GRFVGRGLWP LQEGEYPLGS KLGGKRVGII GLGNIGSLVA
     KRLEAFGCVI CYNSRRRMDS VSYRYFSNVQ RLASESDVLV VACALNKETR HIVNEDVLEA
     LGKDGVVINI GRGASIDEAA LVSALKEGRI AGAGLEVFEN EPKVPPELMS MDSVVLTPHS
     AVFTTESRAD LCQHLICNLE AFFAGKPLIT PVLRLTE
//