ID K7VN42_9CALI Unreviewed; 99 AA.
AC K7VN42;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 08-NOV-2023, entry version 31.
DE SubName: Full=RNA-dependent RNA polymerase {ECO:0000313|EMBL:AFW90111.1};
DE Flags: Fragment;
OS Norovirus GII.4/Jinan/JNHNV0917/2010/CHN.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
OX NCBI_TaxID=1256624 {ECO:0000313|EMBL:AFW90111.1};
RN [1] {ECO:0000313|EMBL:AFW90111.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GII.4/Jinan/JNHNV0917/2010/CHN {ECO:0000313|EMBL:AFW90111.1};
RX PubMed=23754743; DOI=10.1007/s00705-013-1753-0;
RA Sai L., Wang G., Shao L., Liu H., Zhang Y., Qu C., Ma L.;
RT "Clinical and molecular epidemiology of norovirus infection in adults with
RT acute gastroenteritis in Ji'nan, China.";
RL Arch. Virol. 158:2315-2322(2013).
CC -!- FUNCTION: Viral genome-linked protein is covalently linked to the 5'-
CC end of the positive-strand, negative-strand genomic RNAs and subgenomic
CC RNA. Acts as a genome-linked replication primer. May recruit ribosome
CC to viral RNA thereby promoting viral proteins translation.
CC {ECO:0000256|ARBA:ARBA00025359}.
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DR EMBL; JX666262; AFW90111.1; -; Genomic_RNA.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:AFW90111.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 1..99
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFW90111.1"
FT NON_TER 99
FT /evidence="ECO:0000313|EMBL:AFW90111.1"
SQ SEQUENCE 99 AA; 10826 MW; 710E4BDC50E380C1 CRC64;
SKWDSTQQRA VLAAALEIMV KFSPEPHLAQ IVAEDFLSPS VMDVSDFKIS INEGLPSGVP
CTSQWNSIAH WLLTLCALSE VTDLSPDIIQ ANSLFSFYG
//
