ID K7W2C6_9NOST Unreviewed; 527 AA.
AC K7W2C6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Radical SAM domain-containing protein {ECO:0000313|EMBL:AFW95162.1};
GN ORFNames=ANA_C12436 {ECO:0000313|EMBL:AFW95162.1};
OS Anabaena sp. 90.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=46234 {ECO:0000313|EMBL:AFW95162.1, ECO:0000313|Proteomes:UP000010101};
RN [1] {ECO:0000313|EMBL:AFW95162.1, ECO:0000313|Proteomes:UP000010101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90 {ECO:0000313|EMBL:AFW95162.1};
RX PubMed=23148582; DOI=10.1186/1471-2164-13-613;
RA Wang H., Sivonen K., Rouhiainen L., Fewer D.P., Lyra C., Rantala-Ylinen A.,
RA Vestola J., Jokela J., Rantasarkka K., Li Z., Liu B.;
RT "Genome-derived insights into the biology of the hepatotoxic bloom-forming
RT cyanobacterium Anabaena sp. strain 90.";
RL BMC Genomics 13:613-613(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003284; AFW95162.1; -; Genomic_DNA.
DR RefSeq; WP_015080318.1; NC_019427.1.
DR AlphaFoldDB; K7W2C6; -.
DR KEGG; anb:ANA_C12436; -.
DR PATRIC; fig|46234.3.peg.2750; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_5_0_3; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000010101; Chromosome chANA01.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025274; DUF4070.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034530; HpnP-like.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF3; HYPOTHETICAL METHYLTRANSFERASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13282; DUF4070; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00303; hopanoid_C2-methyltransferase; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000010101}.
FT DOMAIN 163..391
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 527 AA; 60453 MW; 7745B99FE132632A CRC64;
MRVLLVYPIF PSTFWSYEKI LALVDRKVLL PPLGLVTVAA ILPQEWEFKL VDRNIRAATE
AEWAWADMVI FSAMIVQKQD LLEQIRAAKR RGKLVALGGP YPTSTPHEVE AAGADYLILD
EGELTLPMFV EAVQRGDKSG VFRAAEKPDV TSTPIPRFDL LEFNAYDMMS VQFSRGCPFQ
CEFCDIIVLY GRKPRTKTPA QLLAELDYLY DLGWRRGVFM VDDNFIGNKR NVKLLLKELK
VWMADHQYPF NFDTEASIDL AQDQEMMELM VDCGFKAVFL GIETPDEDSL QLTKKFQNTR
SSLTESVETI IRTGLRPMAG FIIGFDGEKA GAGDRIVRFA ELAAIPSTTF AMLQALPNTA
LWHRLTKEGR LRENQDGNIN QTTLMNFIPT RPLEELAREY VEAFCALYDP AAYLDRTYRC
FMMLGSPKWT APAKTPEWVV VRALLIVIWR QGFKRQTRWK FWHHFFSILK HNPKVIEQYV
STCAHIEHFM EYRQIVRDEI ESQLAEYLAQ GAETPYVPVK EKAEAVV
//
