GenomeNet

Database: UniProt
Entry: K7WB98_HBV
LinkDB: K7WB98_HBV
Original site: K7WB98_HBV 
ID   K7WB98_HBV              Unreviewed;       203 AA.
AC   K7WB98;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE   Flags: Fragment;
GN   Name=C {ECO:0000256|RuleBase:RU361253, ECO:0000313|EMBL:AFX00712.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFX00712.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFX00712.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1673 {ECO:0000313|EMBL:AFX00712.1};
RX   PubMed=25849554;
RA   Xu H., Zhao M., Lou G., Zheng M., Cao Q., Chen Z.;
RT   "New point mutations in surface and core genes of hepatitis B virus
RT   associated with acute on chronic liver failure identified by complete
RT   genomic sequencing.";
RL   PLoS ONE 10:E0123139-E0123139(2015).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells.
CC       {ECO:0000256|RuleBase:RU361253}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC       {ECO:0000256|RuleBase:RU361253}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JX848307; AFX00712.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 3.
DR   SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT   DOMAIN          1..27
FT                   /note="Hepatitis B virus capsid N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08290"
FT   REGION          177..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..203
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         203
FT                   /evidence="ECO:0000313|EMBL:AFX00712.1"
SQ   SEQUENCE   203 AA;  23348 MW;  939DCD575B7D3479 CRC64;
     MQLFHLCLII SCSCPTVQAS KLCLGWLWDM DIDPYKEFGA SAELLSFLPT DFFPNIRDLL
     DTASALYREA LESPEHCSHH HTALRQAILC WGELMNLATW VGSNLEDPAS RELVVGYVNV
     NMGLKLRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
     RGRSPRRRTP SPRRRRSQSP RRR
//
DBGET integrated database retrieval system