ID K7YPT2_9PROT Unreviewed; 1167 AA.
AC K7YPT2;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:AFX99542.1};
GN ORFNames=A1OE_1371 {ECO:0000313|EMBL:AFX99542.1};
OS Candidatus Endolissoclinum faulkneri L2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Endolissoclinum.
OX NCBI_TaxID=1193729 {ECO:0000313|EMBL:AFX99542.1, ECO:0000313|Proteomes:UP000010077};
RN [1] {ECO:0000313|EMBL:AFX99542.1, ECO:0000313|Proteomes:UP000010077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2 {ECO:0000313|EMBL:AFX99542.1,
RC ECO:0000313|Proteomes:UP000010077};
RX PubMed=23185008; DOI=10.1073/pnas.1213820109;
RA Kwan J.C., Donia M.S., Han A.W., Hirose E., Haygood M.G., Schmidt E.W.;
RT "Genome streamlining and chemical defense in a coral reef symbiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20655-20660(2012).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP003539; AFX99542.1; -; Genomic_DNA.
DR RefSeq; WP_015089040.1; NC_019566.1.
DR AlphaFoldDB; K7YPT2; -.
DR STRING; 1193729.A1OE_1371; -.
DR KEGG; thal:A1OE_1371; -.
DR PATRIC; fig|1193729.4.peg.709; -.
DR eggNOG; COG1197; Bacteria.
DR HOGENOM; CLU_005122_3_2_5; -.
DR Proteomes; UP000010077; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 635..796
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 817..971
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1167 AA; 130881 MW; 159DF9A9D350C56E CRC64;
MNMVGNFNQL FANFPIDVGR VAIASAPEGV EAEAISFLAR SHGLLLHVTC DDTVSNELKR
AVAFFDPELQ VMQLPPWDCL PYDRFSPNKE IMGQRIETLS MLALRKLSAK PALVITTVNA
VLQRVPPKSF FIDSTMALKV GQIISLAKIT DFFVSNGYYR SDMVQECGEY AVHGGTIDVF
PTGTAWPVRL DFFGDTLEEI RCFDPISQRT INNRKDILFL PAREVQLNAV TIQRFRSSYR
SLFGAEVIDD PVYESISAGR FYSGMEHWLP LFYQTISTVL DYVGDAPITL GYQVEKSINN
RFEQITEYHN TRMQMLHCSD TEADNRYRPL DPCAMYLMPD EWDLLMSTRV VGIFTPFAIP
SSADSVIDLG ARSGISLAEA RALGGSAVYD AVRHAVMDEN SQGRRVVIAA YSKSSCELIA
RLFHDHSIDN VDLVANLQAV LALPIATVAT VVLPLKHGYR RGKLTIVSEC EIFGQRLLRQ
SKLGKRRGKH LLREISALTE GDYVVHYEHG IGRYLGLETL EINDALHDVL CLEYLGGDKL
FVLVENIDVL SRYGDHEFKV QLDKLGGLSW RSRKAKVKKR LFDMAEKLIN IAANRELRKT
QPLCLPVANY DKFCSRFPFI ETEDQLKAID DVLADMESSR PMDRLICGDV GFGKTEVALR
AAFVATGQGY QVAVVVPTTL LCRQHYVSFV NRFEGFPIKV AQISRLISTK EANDVRDGLR
NGNINIVVGT HALLSNHNHF DNLGLVIIDE EQHFGVSQKE LLKDMRNAVH VLTMTATPIP
RTTQMALSGL REMSLITTPP VDRLAVQTFV IPYDGMVVRD ALLRERHRGG QTFYVCPRID
DLVHVHEQLL KLILDLRIGV AHGRMASNDL EDVITSFIDG NYDVLISTNI LESGLDIPAA
NTIIIHRSDM FGLAQLYQLR GRVGRSKAQA YAYLTTHPTK LLPPAAKRRL EVLQTFNNLG
ACLSLASHDI EIRGAGNLLG DQQSGQVKEV GIELYHEMLR EAVEVARAGD HIKTKNDTSW
TPQITINMPV LIPPTYISNI SMRMSLYRRI AMLINQEEID GFIVELVDRF GPLPVEVDNL
LKIMTIKLLC RVAGVEKIDA GSKGAIIAFR NNSFAYPDKL ITFMQQQADF VQFRPDHRMI
YRCTWNDSDK LLRGLIGLMK KLAAVVV
//
