ID K8E7J5_CARML Unreviewed; 280 AA.
AC K8E7J5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Uncharacterized oxidoreductase YtbE {ECO:0000313|EMBL:CCO12879.2};
DE EC=1.-.-.- {ECO:0000313|EMBL:CCO12879.2};
GN Name=ytbE {ECO:0000313|EMBL:CCO12879.2};
GN ORFNames=BN424_3458 {ECO:0000313|EMBL:CCO12879.2};
OS Carnobacterium maltaromaticum LMA28.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Carnobacterium.
OX NCBI_TaxID=1234679 {ECO:0000313|EMBL:CCO12879.2, ECO:0000313|Proteomes:UP000000212};
RN [1] {ECO:0000313|Proteomes:UP000000212}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LMA28 {ECO:0000313|Proteomes:UP000000212};
RX PubMed=23405327; DOI=10.1128/genomeA.00115-12;
RA Cailliez-Grimal C., Chaillou S., Anba-Mondoloni J., Loux V., Afzal M.I.,
RA Rahman A., Kergourlay G., Champomier-Verges M.C., Zagorec M., Dalgaard P.,
RA Leisner J.J., Prevost H., Revol-Junelles A.M., Borges F.;
RT "Complete Chromosome Sequence of Carnobacterium maltaromaticum LMA 28.";
RL Genome Announc. 1:0-0(2013).
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DR EMBL; HE999757; CCO12879.2; -; Genomic_DNA.
DR RefSeq; WP_015077789.1; NC_019425.2.
DR AlphaFoldDB; K8E7J5; -.
DR STRING; 1234679.BN424_3458; -.
DR GeneID; 83604634; -.
DR KEGG; cml:BN424_3458; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_0_1_9; -.
DR OrthoDB; 191683at2; -.
DR Proteomes; UP000000212; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CCO12879.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000212}.
FT DOMAIN 21..267
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 54
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 116
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 83
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 280 AA; 32042 MW; BC9C8DF9D0B12699 CRC64;
MNINFENQVT LNNEVNMPWI GLGVFRVEDH AELVEAIKLA IVQGYRSIDT ASIYGNEEAV
GEGIRQGIVA AGISRKELFV TSKVWTADMG FEEVEKAYQV SLDKLGLDYL DLYLIHWPVS
GKFIPTWKKM EELYQDGKIR SIGVSNFQIH HLEELFAETS IKPVINQVEY HPKLTQLELQ
NYLKQHNIQM EAWSPLMNGE ILTNPVILAI AERHGKTAAQ VILRWDLQNG VITIPKSTNE
QRLAQNKDIV DFNLSEKDMQ QIQQLNENHR IGPDPDNFDF
//
