ID   K8GS77_9CYAN            Unreviewed;       721 AA.
AC   K8GS77;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
DE   Flags: Precursor;
GN   ORFNames=OsccyDRAFT_0850 {ECO:0000313|EMBL:EKQ70554.1};
OS   Leptolyngbyaceae cyanobacterium JSC-12.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Leptolyngbyales; Leptolyngbyaceae.
OX   NCBI_TaxID=864702 {ECO:0000313|EMBL:EKQ70554.1, ECO:0000313|Proteomes:UP000001332};
RN   [1] {ECO:0000313|EMBL:EKQ70554.1, ECO:0000313|Proteomes:UP000001332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSC-12 {ECO:0000313|EMBL:EKQ70554.1,
RC   ECO:0000313|Proteomes:UP000001332};
RG   DOE Joint Genome Institute;
RA   Brown I., Huntemann M., Wei C.-L., Han J., Detter J.C., Han C., Tapia R.,
RA   Chen A., Kyrpides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA   Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L.,
RA   Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RT   "Improved high quality draft of Oscillatoriales sp. JSC-12.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKQ70554.1}.
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DR   EMBL; AJUB01000005; EKQ70554.1; -; Genomic_DNA.
DR   AlphaFoldDB; K8GS77; -.
DR   STRING; 864702.OsccyDRAFT_0850; -.
DR   PATRIC; fig|864702.5.peg.892; -.
DR   eggNOG; COG1505; Bacteria.
DR   HOGENOM; CLU_011290_1_1_3; -.
DR   Proteomes; UP000001332; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EKQ70554.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001332};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..721
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003918585"
FT   DOMAIN          41..444
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          501..715
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   721 AA;  81168 MW;  1BE4AC3373A23838 CRC64;
     MKNRIILGCV GLVLAFICHS GFRFTVADAM TSANFSFTYP SSPKGNQVDT YHGTTVADPY
     RWLEDPDSPE TKAWIEAQNT LTFGFLAQIS ERDRIKQRLT QLWNYEKYGI PFKQGDRYFF
     FKNDGLQNQS VLYTLKSLDD QPTVLLDPNK LSDDGTVALS GLSISEDGSL MAYGLSTSGS
     DWQDWKVRQV DTGEDLSDLV QWVKFSSASW TKDGKGFFYS RYDAPKAKTK LEEVNYYQKL
     YYHRLGTPQS EDILIYQRPD QKEWGFSGNV TEDGRYLIIS VWLGTDTRNL IFYKDLATPD
     APVVELIDTF EAEYRFIDSE GTRFWFCTDL NAPRSRVIAI DITNSDRAQW QEIIPEATET
     LQGVSLLNHQ FVASYLKDAY TQIKIFDLNG RPVRKVELPG IGSAGGFGGK REDTETFYSF
     TSFTTPTTIY RYDMVTGKST VFRQPNVDFN PQDYETHQVF YRSQDGTQVP MFIVHKKGLK
     LDGTNPTLLY GYGGFGVSLT PSFSVSLLVW MEMGGVYALP NLRGGGEYGE EWHQAGMKHK
     KQNVFDDFIA AAEWLINHKY TSSKKLAIAG GSNGGLLVGA CMTQRPELFG AALPDVGVMD
     MLRFHKFTIG WAWTSEYGSP ENPDDFKTLY AYSPLHNLKP NVDYPATMIT TADHDDRVVP
     AHSFKFAAAL QAAHKGPDPV LIRIETKAGH GAGKPTAKLI EETADKWAFL VKTLAMPLEM
     Q
//