ID K8WWR2_9GAMM Unreviewed; 645 AA.
AC K8WWR2;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0008006|Google:ProtNLM};
GN ORFNames=OOA_01200 {ECO:0000313|EMBL:EKT65109.1};
OS Providencia burhodogranariea DSM 19968.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Providencia.
OX NCBI_TaxID=1141662 {ECO:0000313|EMBL:EKT65109.1, ECO:0000313|Proteomes:UP000009336};
RN [1] {ECO:0000313|EMBL:EKT65109.1, ECO:0000313|Proteomes:UP000009336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19968 {ECO:0000313|EMBL:EKT65109.1,
RC ECO:0000313|Proteomes:UP000009336};
RX PubMed=23145767; DOI=10.1186/1471-2164-13-612;
RA Galac M.R., Lazzaro B.P.;
RT "Comparative genomics of bacteria in the genus Providencia isolated from
RT wild Drosophila melanogaster.";
RL BMC Genomics 13:612-612(2012).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKT65109.1}.
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DR EMBL; AKKL01000002; EKT65109.1; -; Genomic_DNA.
DR RefSeq; WP_008910289.1; NZ_KB233222.1.
DR AlphaFoldDB; K8WWR2; -.
DR STRING; 1141662.OOA_01200; -.
DR PATRIC; fig|1141662.3.peg.244; -.
DR eggNOG; COG3962; Bacteria.
DR HOGENOM; CLU_013748_6_0_6; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000009336; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd02003; TPP_IolD; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 6..134
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..353
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 440..599
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 645 AA; 70637 MW; 5322CF0E9182F786 CRC64;
MNKQTMTTAQ ALVKFLNQQY VEVDGEQYPF IQGIFTIFGH GNVVGLGQAL EEAPGHLQVY
QGCNEQGMAH IATGFAKQKK RKQICAVTSS VGPGAANMVT AAATATANRI PLLLLPGDTF
ATRQPDPVLQ QVEQYGDGTL STNDCFRPVS RYWDRVSRPE QLMAAMINAM RVLTDPADTG
AVTICLPQDV QGEAWDYPDY FFAKRVHRIE RRPATTVSLA EAVSLIRRKQ KPLLVCGGGV
RYSEAHDAFR IFAEHFAIPF GETQAGKSAI VASHPLNVGG IGTTGGLAAN LLAKEADLVI
GVGTRFTDFT TASKSLFSHP NVEFLNINVA EFDACKLDAL KLVADAKEGL TALDTLLQGS
GYQAQWGDSI QQAKQQWQTE LTRLFSIQYR PLDFIPEIAG HLDDKIDEYR EALGTELTQT
RVLGLMQQYM EDDAIVVGAA GSLPGDLQRI WFPKYPDTYH LEYGYSCMGY EIAAAVGAKI
AAPEQPVYAM VGDGSYLMLH SELQTAIQEN LKITILLFDN AGFGCINNLQ MSQGMGSFGT
ENRHRNPKTG KMDGPLVKVD FAKNAESYGC KSYRVHDEAQ LIAAIEDAKS HSGCVLIDIK
VLPKTMTNGY EAWWRTGTAQ VAQNPEIVCA ADKIKEMVAN HVRQY
//