ID K8ZMN9_9ENTE Unreviewed; 716 AA.
AC K8ZMN9;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Lipoteichoic acid synthase LtaS Type IIc {ECO:0000313|EMBL:EKU27813.1};
GN ORFNames=C683_0278 {ECO:0000313|EMBL:EKU27813.1};
OS Catellicoccus marimammalium M35/04/3.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Catellicoccus.
OX NCBI_TaxID=1234409 {ECO:0000313|EMBL:EKU27813.1, ECO:0000313|Proteomes:UP000016057};
RN [1] {ECO:0000313|EMBL:EKU27813.1, ECO:0000313|Proteomes:UP000016057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M35/04/3 {ECO:0000313|EMBL:EKU27813.1,
RC ECO:0000313|Proteomes:UP000016057};
RX PubMed=23405330;
RA Weigand M.R., Ryu H., Bozcek L., Konstantinidis K.T., Santo Domingo J.W.;
RT "Draft Genome Sequence of Catellicoccus marimammalium, a Novel Species
RT Commonly Found in Gull Feces.";
RL Genome Announc. 1:E00019-12(2013).
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LTA synthase family.
CC {ECO:0000256|ARBA:ARBA00009983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU27813.1}.
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DR EMBL; AMYT01000008; EKU27813.1; -; Genomic_DNA.
DR AlphaFoldDB; K8ZMN9; -.
DR STRING; 1234409.C683_0278; -.
DR PATRIC; fig|1234409.3.peg.249; -.
DR eggNOG; COG1368; Bacteria.
DR Proteomes; UP000016057; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.170; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000016057};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..555
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 661..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 309
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 260
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 309
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 426
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 486
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 487
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 716 AA; 82322 MW; 5FD27C653D1D8260 CRC64;
MKKFSLKKVL NTRMGYFALL ALITWLTNIY AYFTTFNLGI QSPFQYFILI INPIATTLLL
LSIGLYCKKG KTAYILMTTI AILMNILLFS NVVYYREFSD FITVNSILGV GSVASGLKSD
IFKLIHPHDI VYWISYIVIF ILFATKYLKV DQRPLPKRVA FAMSSLAVFI FGANLTLAEI
DRPELLSRTF SHDYMVKYLG INAFTTYDGI QTYKIDQRRA QASEMDLTRV EKYVKDHYAA
PNPKYFGMAK GRNVVVIHLE SLQQFIIDYK YKDKDGKQYE VTPFLNKLFH DKQTFAFDNF
FHQVGSGKTS DAETLMENSL FGLSQGPIMV QLGGKNTFQA APNILKQNGN YTSAVFHGND
GTFWNRNEAY KHFGFDYFFD SSYFDLNPSN SFQYGLHDKY MIKDSIKYLE RMQQPFYVKF
LNVSNHYPFA PFKGKESGFP IADTGDDTVN GYFATANYLD EAVRELFDYF KKSGLYDKSI
FILYGDHYGI SNTRAKNALS PLLGKSPETW TDFDDMQMQR VPYMIHIPGQ DKGFIDHTYG
GQVDNLPTIL HLLGINTKNY IELGQDLFSK ENQQIVAFRN GNYVTPQFTS IDGEVYSNKT
GKPIKKPTKK QQKTINYDAK QVEEQLQVSD EINNGDLLRF ANNGIKPVDP SQFNYKDQME
RLQKEEKEKG KDSTSVYNKN HNQSTTSLFQ SKSYQELHGK TKYSTSENSK DKEEEK
//
