ID K9DE42_9BURK Unreviewed; 747 AA.
AC K9DE42;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=RelA/SpoT family protein {ECO:0000313|EMBL:EKU82929.1};
GN ORFNames=HMPREF9710_01940 {ECO:0000313|EMBL:EKU82929.1};
OS Massilia timonae CCUG 45783.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=883126 {ECO:0000313|EMBL:EKU82929.1, ECO:0000313|Proteomes:UP000009874};
RN [1] {ECO:0000313|EMBL:EKU82929.1, ECO:0000313|Proteomes:UP000009874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 45783 {ECO:0000313|EMBL:EKU82929.1,
RC ECO:0000313|Proteomes:UP000009874};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Massilia timonae CCUG 45783.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU82929.1}.
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DR EMBL; AGZI01000021; EKU82929.1; -; Genomic_DNA.
DR RefSeq; WP_005665921.1; NZ_JH992922.1.
DR AlphaFoldDB; K9DE42; -.
DR STRING; 47229.LO55_2525; -.
DR GeneID; 84812125; -.
DR PATRIC; fig|883126.3.peg.1972; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_4; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000009874; Unassembled WGS sequence.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009874}.
FT DOMAIN 80..179
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 421..482
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 672..747
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 83941 MW; 45AA58349CA08922 CRC64;
MNLSPDSTNT RNPAAPRERR ADNRPPDYLE PVAPGVASVT QLITMLSEYL TPAELKKVKE
AYRFSDEMHL GQVRKSGEPY ISHPIAVAEI CAEWKLDAQA IMAALLHDVI EDQDVKKDEL
IERFGAQVAN LVDGLSKLEK IEFQSQLEAQ AENFRKMLLA MASDVRVILI KLADRLHNMR
TLGVMVPAKK RRIAGETMEV YVPIAHRLGL NNIYRELQDL SFSHLYPLRY QTLSKAIKAA
RGNRREVVKK ILEAVKNQLA TSGLQFEVYG REKTLYGIYK KMRNKHLSFS QVLDVYGFRV
VVDSVPNCYV ALGTLHALYK PMPGKFKDYI AIGKINGYQS LHTTLIGPYG TPVEFQIRTQ
EMHRTAESGV AAHWLYKTGD SNMSDLQQRT HAWLQSLLDI QQQTGDSAEF LEHVKVDLFP
DSVYVFTPKS KIIALPRGAT ALDFAYSIHT GIGDHTVGVK INNEDQPLRT ELHNGDIVEI
ITDPESRPSP TWLTFVRTGK ARSAIRHHLR AIDVNESVDL GQELLAQALA VRNIKPDLSD
AVIERLLAET SAKSMEEMYA DIGIGKRMPA LVARHIFGLM EGDPELLPSS KPLPASEIAP
VTIYGSEGVA VQLAPCCLPI PGDQITGQLR RDQALVVHTC DCLPAKRIRA KEPDRWIAVQ
WGDELNRRFD CRIRLLINNE KGILARVAAE IGESDANITY VGMDEDDEHS MTQLRFTIQI
KDRVHLAQLI RNLRRVAGVN RVERERS
//
