ID K9DGD6_9BURK Unreviewed; 742 AA.
AC K9DGD6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN ORFNames=HMPREF9710_00978 {ECO:0000313|EMBL:EKU83799.1};
OS Massilia timonae CCUG 45783.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=883126 {ECO:0000313|EMBL:EKU83799.1, ECO:0000313|Proteomes:UP000009874};
RN [1] {ECO:0000313|EMBL:EKU83799.1, ECO:0000313|Proteomes:UP000009874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 45783 {ECO:0000313|EMBL:EKU83799.1,
RC ECO:0000313|Proteomes:UP000009874};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Massilia timonae CCUG 45783.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU83799.1}.
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DR EMBL; AGZI01000009; EKU83799.1; -; Genomic_DNA.
DR AlphaFoldDB; K9DGD6; -.
DR STRING; 47229.LO55_1586; -.
DR PATRIC; fig|883126.3.peg.982; -.
DR eggNOG; COG0339; Bacteria.
DR HOGENOM; CLU_001805_4_0_4; -.
DR Proteomes; UP000009874; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06456; M3A_DCP; 1.
DR Gene3D; 1.10.1370.40; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR034005; M3A_DCP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR43660; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR43660:SF1; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000009874};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT TRANSMEM 33..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..733
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 742 AA; 81933 MW; 4481BC4D8758DAF7 CRC64;
MQACYDLQRT AVELAPTAPS LVFAKDLMTR PQLLIIAASV ALAHATAIAA PAAPALDASN
PFAQPSSLPL NYPAFDKIKD AHFLPAFHAG MREELREVEA IAGDKAAPTF ENTIVALERS
GQLLARVVAT FSNLQGANTN DTLDAVDREM SPKLAAHSDA IHLNPKLFAR VKALHDKRDT
LGLDAESVHL LERYYKEFVR AGANLSKADQ AKLKKFNGEI ASLQSDFQQR VLKGANAAAL
IVNTRAELAG MSDAQISAAA DEAAKRGQKG KFAIPIVNTS SQPALSFLTS RATRERLMKA
SLERGTHGGQ FDTTEQVLRL VKLRAERAVL LGYPNFAAYS QELETARNPA AVNKLLGDLA
APAVNNAKKE AAEIQKVIDK EGGKYQVAAW DWPMYQDKVR AATFNFDESQ LRPYFELNRV
LVDGVFFAAT KEFGITFKQR TDLPVYNPDV TVYDIFDVDG KPLAIFIFDP YARGNKQGGA
WMNEYVSQSH LLGHKPVIGN HLNIPKPPKG EPTLLTYDEV VTTFHEFGHA LHGMFSNVKY
PKFSGTNVPR DFVEYPSQVN EMWVTWPEVL ANYAKHHQTG APMPKDLLDK VVASKKFAQG
YRTTEYLAAA LLDQRWHQLT PSQIPTDVLS FEAKALQDAG VAYPPVPPRY RTGYFSHSMG
GGYSAGYYAY LWSERLDAET VKWFTESGGL TRKNGDHFRK TLLSRGGTAE AMDLFRDFRG
RDPEIGPLLE RRGLVETKPS SN
//
