ID K9EYI0_9ACTO Unreviewed; 660 AA.
AC K9EYI0;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9233_00145 {ECO:0000313|EMBL:EKU96057.1};
OS Actinobaculum massiliense ACS-171-V-Col2.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinobaculum.
OX NCBI_TaxID=883066 {ECO:0000313|EMBL:EKU96057.1, ECO:0000313|Proteomes:UP000009888};
RN [1] {ECO:0000313|EMBL:EKU96057.1, ECO:0000313|Proteomes:UP000009888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-171-V-Col2 {ECO:0000313|Proteomes:UP000009888};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinobaculum massiliae ACS-171-V-COL2.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU96057.1}.
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DR EMBL; AGWL01000001; EKU96057.1; -; Genomic_DNA.
DR RefSeq; WP_007000363.1; NZ_JH992955.1.
DR AlphaFoldDB; K9EYI0; -.
DR STRING; 202789.GCA_001457435_00218; -.
DR PATRIC; fig|883066.3.peg.147; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_5_11; -.
DR Proteomes; UP000009888; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009888};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..281
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 324..630
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 70319 MW; 20FAC2821B5E3E28 CRC64;
MDESRNNGES ASSRHPRRDG KRNGNKDGKQ KSQRFDVRRV LARRRASASG DTAMFHSRTK
LLIIAFLLCI ALLAVRLFDL QFLRSDGLAA SADAFRTRTY TLHAERGDIK DSSGSVLATS
VERYNVGVNQ KLIGEYVHYK TDEDGHLIRD AAGDPVVAGT GAAEAAKVLA PILGLDRAQL
GGTLLGGEEK TTFAYIAKDI SPETWRTISA LQIPGIEPEQ YMKRDYPNGP VAGNIIGYVG
ETAQNPNAVG QAGIERSQED VLAGVDGSYT VQTAGGGAVV PNGTANRVEP VNGRDVRLTI
DRDLQNSLME ALDRSVAANS AQWGSAVVIE IGTGRVLALA DSNSPDPSNL KETDPSNWGS
RAVQAPVEPG STGKIPTFSA AIDQGAVNPL TTFTVPDRIT MPNGETISDN DPHSTQGMTV
AGIMALSYNT GLIQIGDTVQ DSTRYGYMRA FGIGSPTGIE LPAESAGILR DPSTWDNRTR
YTTMFGQGWA ATTLQMGQIA ATIGNGGVYM PIHIIDSVTD EHGNEVATVP GESHRVISEE
SAQTMLNMMQ GVTQPGSTGW MARVEGYNVA GKTGTAQVPD KNGNLTRRVG TFIGVVPAEN
PQIAIAVTVY GGAGAGYGGT TAAPVFKEVT EFATRQLGIP PSEVPLFKYP WYQWEMGKQK
//
