ID   K9FTC2_PEND1            Unreviewed;       825 AA.
AC   K9FTC2;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PDIP_81160 {ECO:0000313|EMBL:EKV06018.1};
OS   Penicillium digitatum (strain Pd1 / CECT 20795) (Green mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1170230 {ECO:0000313|EMBL:EKV06018.1, ECO:0000313|Proteomes:UP000009886};
RN   [1] {ECO:0000313|Proteomes:UP000009886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd1 / CECT 20795 {ECO:0000313|Proteomes:UP000009886};
RX   PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA   Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA   Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT   postharvest pathogen of citrus.";
RL   BMC Genomics 13:646-646(2012).
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037882}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKV06018.1}.
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DR   EMBL; AKCU01000490; EKV06018.1; -; Genomic_DNA.
DR   RefSeq; XP_014532273.1; XM_014676787.1.
DR   AlphaFoldDB; K9FTC2; -.
DR   GeneID; 26236432; -.
DR   KEGG; pdp:PDIP_81160; -.
DR   HOGENOM; CLU_006921_0_1_1; -.
DR   OrthoDB; 1416at2759; -.
DR   Proteomes; UP000009886; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR024775; DinB-like.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR03439; methyl_EasF; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF12867; DinB_2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          29..332
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   DOMAIN          371..493
FT                   /note="DinB-like"
FT                   /evidence="ECO:0000259|Pfam:PF12867"
FT   DOMAIN          554..823
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   REGION          607..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  93837 MW;  0F7E40002B3DE0A8 CRC64;
     MSPTLLRNVD TVEIVNIHQC DMEFSLVDDV YKNLDPPAGK QRTFPTLLLY DAKGLKLFEE
     ITYLDEYYLT NTEIEILKKH AKKIVAHIPE NAQLVELGSG NLRKIEILLR ECERSEKKVD
     YYALDLSLGE LQRTFSEISP ESFIHVGFHG LHGTYDDAVG WLKSPENRKR PTLVLSMGSS
     MGNFSPPDAA DFLGGFSKLL GPSDFLLVGL DACKNPEKVF RAYNDSKGIT RKFYENGLLH
     ANRVLGFKAF KADEWEILTD YDNREGRHQA FYVSKVDVII NGIKIRKGEK LIFEEAWKYG
     RNERDQLWRN ANLISQVEFG NSTDDYHLHL LSPAALDLSM NPSKYAAQPI PSIENFQSLW
     TAWDLATRTM VPHEELLSQP IKLRNALIFY FGHIPTFLDI HLTRALQEES TEPSNYKTIF
     ERGIDPDVED PQQCHSHSEI PDEWPPLDEI LDYQDRVRNR ALSILQQGYA SQDRALGEAL
     WIGYEHEAMH LETFLYMLIQ SDKTLPPTGV DRPDFEQINR QAKINKKPNK WFRIPRQTIE
     IGLNDSNEEV VPNQSFGWDN EKPQRKVTVH AFEAQARPIT NGEYAKYIQD KGIKTYPASW
     VFKPSQDNPV SKGISSSDAQ AGSSSSPAGL SLKDITVRTV FGPVALEVAQ DWPLAASYDE
     VASYAKCMKC RIPTFEETRS IYHYSDQLKG DRVTNDHRNG VNGLANDSKP NSTDQTVFRD
     LTGCNVGFNN WHPIPVTSNG DQLAGQGEMG GVWEWTSTPL MPHDDFKAMD IYPGYTSDFF
     DGKHNIVLGG SWATLPRIAG RTTFVNWYQH NYRYAWAGAR LVRDI
//