ID K9H4B3_PEND1 Unreviewed; 1225 AA.
AC K9H4B3;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=PDIP_20780 {ECO:0000313|EMBL:EKV19921.1};
OS Penicillium digitatum (strain Pd1 / CECT 20795) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170230 {ECO:0000313|EMBL:EKV19921.1, ECO:0000313|Proteomes:UP000009886};
RN [1] {ECO:0000313|Proteomes:UP000009886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pd1 / CECT 20795 {ECO:0000313|Proteomes:UP000009886};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV19921.1}.
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DR EMBL; AKCU01000142; EKV19921.1; -; Genomic_DNA.
DR RefSeq; XP_014537253.1; XM_014681767.1.
DR AlphaFoldDB; K9H4B3; -.
DR GeneID; 26230400; -.
DR KEGG; pdp:PDIP_20780; -.
DR HOGENOM; CLU_002173_2_4_1; -.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000009886; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 849..1225
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1193
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1225 AA; 138403 MW; 19A2D4FA98538BEE CRC64;
MFQSFTGNSR RPRQVNLSGR ATNPFVAFPG NPQTRQTPHV ANPESAVAIA QRERALRQHE
RDRQTASRTV QRVWRGYQSR KRTYKGWKSE WDTFEWNRVT SALGLDDDRG PMTELERLEC
LARLSAPPYP TAEQCLDQLR LLVQFVGLVR NKEDVLRLVY FCNVFEETFH FLPTIATEND
WTELLKRLAV AILHALGSSR DSPTHDAAVL PLLRTIVFLV DLIPKKMATI AQQYYETMAL
LTKNIGLFGG TPSPEHVTNA VLALLRPITS ETMAAYEALA MSYLTIPNLP AYLGELDGLA
HKINYKLLAP AIESCIPMTK ERLSTDDVEG IEGRLWLLAY LIFFHRYALP GQANLQAPDL
AFLNVVSGLL NSTSIYLTRC FEVDENGLDP VRAPCLDQFV ADQVSSLVNQ SSITGLLSRI
RTFHLSHTDV SNNEYNASKE AKILATYALN LLRVFPRRGD DIRMWLYLGS APSAGLTAGE
PGAKIPAIKY FWQASKSSQI FHTISKDSTQ VLPLLQLPQG GDTEDQEQEW TIILLFFELY
TFLLKVMDDE EFFSSASPYA ASPNVLSSWT KESALPLQDI KDMTIFLKNL AFTLYWNIAD
LTKKGPVLSS AVDLRSYFNN TTQVSGSIDR TEVEAKKEIN DLPGVIGIPL DYFKGLVTGL
LRMLHERDSR RKFLPQNHWL MTDRFDMEGF IPAVVAEEEK RHEFQDDDEE SEPDLLDAEY
REPSPLVGNS HARRLIQIQA MRNSQRRQAH NNALAAIAPR LEILRNMPFF IPFATRVQIF
RQFIFRDQQR RRKGFVDPES WRLSVAQNAM INGPPEGAAD ILARHHADIR RESVFEDAFS
QYYGLGDGLK EPIQISFIDQ FGAMEAGIDG GGVTKEFLTS ITSQAFKTDD YESMFAENDH
HLLYPSPIAV DQLKKVLSEA GLTNSSPEWQ DDVRGLLRRY EFLGRIIGKC LYEGILVDVD
FAPFFLLKWA LTGGSRSAVK ESSYRANLND LKDLDEGLYQ GLLQLKNYPG NVEDFGLDFT
INNKIRMPSG ANRTVTAELK PNGSQTAVTN KNRLVYISYV ARYRLQLQPA LQTNAFLQGL
GQIVQPAWLS MFNQSELQTL VSGDKADIDV EDLRRNTLYG GVYVIGDDNL EHPTIALFWQ
VMHEMTNEER QKVIRFVTST PRAPLLGFSH LRPNFSIRDS SEDQERLPST STCVNLLKLP
RYSDADTLRS KLLYAVSSGA GFDLS
//
