ID K9IMV1_DESRO Unreviewed; 785 AA.
AC K9IMV1;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Desmodus rotundus (Vampire bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC Desmodontinae; Desmodus.
OX NCBI_TaxID=9430 {ECO:0000313|EMBL:JAA49048.1};
RN [1] {ECO:0000313|EMBL:JAA49048.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:JAA49048.1};
RA Francischetti I.M.B., Assumpcao T.C.F., Ma D., Vicente E.C.,
RA Ribeiro J.M.C.;
RT "The Vampirome: Transcriptome and Proteome Analysis of the Submandibular
RT and Accessory Glands of the Vampire Bat and Vector of Human Rabies,
RT Desmodus rotundus.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX21/DDX50
CC subfamily. {ECO:0000256|ARBA:ARBA00006517}.
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DR EMBL; GABZ01004477; JAA49048.1; -; mRNA.
DR AlphaFoldDB; K9IMV1; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17944; DEADc_DDX21_DDX50; 1.
DR CDD; cd12936; GUCT_RHII_Gualpha_beta; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.30.70.2280; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR012562; GUCT.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR47963:SF8; ATP-DEPENDENT RNA HELICASE DEAD; 1.
DR PANTHER; PTHR47963; DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08152; GUCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:JAA49048.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 219..398
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 431..575
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87615 MW; B7769D50BA8DBA14 CRC64;
MPGKLLSDTD LESNAALVKM ETPRKQNEKK ARKEKPKSNK TEKAAEEMEE AISPKAKKVK
KKAGPSEVDM NSPKSKKEKN KEEPSQDDVI SPKIKSVKKP KEPMEKKDIS SKTKKVKKNE
EPSEEEVGAP KPKKMKKEKE MNGEVGEKSS KLKNGFSFSG PDSNCNEAAS EESNSELEQE
IPVEQKEGAF SNFPISEETI KLLKARGVTF LFPIQAKTFH HVYSGKDLIA QARTGTGKTF
SFAIPLIEKL LGELQERKRG RAPQVLVLAP TRELANQVSK DFIDITKKLA VACFYGGTPY
GGQLERMRNG IDILVGTPGR IKDHLQNGKL DLTKLKHVVL DEVDQMLDMG FADQVEEILS
VAYKKDSEDN PQTLLFSATC PHWVFNVAKK YMKSTYEQVD LIGKKTQKTA ITVEHLAIKC
HWTQRAAVIG DVIRVYSGFH GRTIIFCETK KEAQELSQNA SIRQDAQSLH GDIPQKQREI
TLKGFRNGDF GVLVATNVAA RGLDIPEVDL VVQSSPPKDV ESYIHRSGRT GRAGRTGVCI
CFYQHKEEYQ LAQVEQKAGI KFKRIGVPSA TEIIKASSKD AIRLLDSVPP TAISHFKQSA
EKLIEEKGAV EALAAALAHI SGATSVDQRS LINSESGFVT MILKCSIEMP NISYAWKELK
EQLGEEIDSK VKGMVFLKGK QGVCFDVRTA AVTEIQEKWH DSRRWQLSVA TEQPELEGPR
EGYRNFRGQR EGNRGHRGQR EGNRNFRGQR EGSRNFRGQR SGGGSRNNRF QNKGQKRSFS
KAFGQ
//
