ID K9ITU2_DESRO Unreviewed; 715 AA.
AC K9ITU2;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE SubName: Full=Putative phospholipase c {ECO:0000313|EMBL:JAA52600.1};
DE Flags: Fragment;
OS Desmodus rotundus (Vampire bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC Desmodontinae; Desmodus.
OX NCBI_TaxID=9430 {ECO:0000313|EMBL:JAA52600.1};
RN [1] {ECO:0000313|EMBL:JAA52600.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:JAA52600.1};
RA Francischetti I.M.B., Assumpcao T.C.F., Ma D., Vicente E.C.,
RA Ribeiro J.M.C.;
RT "The Vampirome: Transcriptome and Proteome Analysis of the Submandibular
RT and Accessory Glands of the Vampire Bat and Vector of Human Rabies,
RT Desmodus rotundus.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; GABZ01000925; JAA52600.1; -; mRNA.
DR AlphaFoldDB; K9ITU2; -.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10346; SH2_SH2B_family; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035057; SH2B1_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF3; SH2B ADAPTER PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 565..663
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 162..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA52600.1"
SQ SEQUENCE 715 AA; 75286 MW; BF0F802C0F187AA7 CRC64;
VCASLPSAAA AAHPVSSGRF PLCCPSPQVP PLHFLGTIMN GAPSLEDGAF PSPPPLPPPP
PPSWREFCES HARAAALDFA RRFRLYLASH PQYAGPGAEA AFSRRFAELF LQHFEAEVAR
ASGSLSPPIV APLSPGVEIP AHDLSLESCR VGGPLAVLGP SRSSEDLAGP LPSSVSSSST
TSSKPKLKKR FSLRSVGRSV RGSVRGILQW RGTVDPPSPA GPLETSSGPP VLGGNSNSNS
SGGAGTIGRG LVSDGTSPGD RWTHRFERLR LSRGGGTLKD GAGMVQREEL LSFMGAEEAA
PDPAGVGRGG GAAGPTSGGG GQPQWQKCRL LLRSEGEGGG GSRLEFFVPP KASRPRLSIP
CSTITDVRTA TALEMPDREN TFVVKVEGSS EYILETADAL HVKAWVSDIQ ECLSPGPCPA
TSPHPMSLPL APGTSFLTRE NTDSLELPCL NHSESLPSQD LLLGPSESND RLSQGAYGGL
SDRPSASISP SSASIAASHF DSMELLPPEL PPRIPIEEGL PAGTVHPLSA PYPPLDTPET
ATGSFLFQGE SEGGEGDQPL SGYPWFHGML SRLKAAQLVL AGGTDSHGVF LVRQSETRRG
EYVLTFNFQG KAKHLRLSLN EEGQCRVQHL WFQSIFDMLK HFRVHPIPLE SGGPSDVVLG
SYVVSSQRQQ GREQAGSHAG VCEGDRCYPD ASSTLMPFGA SDCVTEHLPR LTPAP
//
