ID K9J4T3_PIG Unreviewed; 488 AA.
AC K9J4T3;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Anthrax toxin receptor {ECO:0000256|PIRNR:PIRNR038023};
GN Name=ANTXR2 {ECO:0000313|EMBL:JAA53721.1,
GN ECO:0000313|Ensembl:ENSSSCP00000049805.1,
GN ECO:0000313|VGNC:VGNC:85365};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:JAA53721.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000049805.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049805.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAA53721.1}
RP NUCLEOTIDE SEQUENCE.
RA Dawson H.D., Chen C.T.;
RT "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT Sequencing.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HDB86048.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000049805.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095,
CC ECO:0000256|PIRNR:PIRNR038023}.
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DR EMBL; DQIR01230571; HDB86048.1; -; Transcribed_RNA.
DR EMBL; GACC01000086; JAA53721.1; -; mRNA.
DR RefSeq; XP_003129419.3; XM_003129371.5.
DR STRING; 9823.ENSSSCP00000049805; -.
DR PaxDb; 9823-ENSSSCP00000009870; -.
DR Ensembl; ENSSSCT00000037987.3; ENSSSCP00000049805.1; ENSSSCG00000009256.5.
DR GeneID; 100514416; -.
DR KEGG; ssc:100514416; -.
DR CTD; 118429; -.
DR VGNC; VGNC:85365; ANTXR2.
DR eggNOG; ENOG502QT7Y; Eukaryota.
DR GeneTree; ENSGT00940000156320; -.
DR OrthoDB; 5397560at2759; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000009256; Expressed in stomach and 42 other cell types or tissues.
DR Genevisible; K9J4T3; SS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR CDD; cd01474; vWA_ATR; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR017360; Anthrax_toxin_rcpt.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF038023; Anthrax_toxin_receptor_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038023-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038023};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR038023,
KW ECO:0000256|PIRSR:PIRSR038023-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:K9J4T3};
KW Receptor {ECO:0000256|PIRNR:PIRNR038023, ECO:0000313|EMBL:JAA53721.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..488
FT /note="Anthrax toxin receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014582156"
FT TRANSMEM 318..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..213
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 355..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 52
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 54
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 118
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT DISULFID 39..218
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-2"
SQ SEQUENCE 488 AA; 53335 MW; 3209EE974207798B CRC64;
MVAGPFPARR PGSWLVPGLW LLALSGPGAL VSAQEQPSCS GAFDLYFVLD KSGSVANNWI
EIYNFVHQLT ERFVSPQMRL SFIVFSSQAT IILPLTGDRG KISEGLDNLK RVSPVGETYI
HEGLKLANEQ IEKAGGLKTS SIIIALTDGK LDGLVPSYAE KEAKISRSLG ARVYCVGVLD
FEQAQLERIA DSKEQVFPVT GGFQALKGII NSILAQSCTE ILELRPSSVC VGEEFQIVLN
GRGFSLGSRK GSVLCTYTVN ETYTKSVMPV SVEHNSMLCP APTLHEVGET LDVSVSFNGG
KSVISSSLIV TATECSNGIA AVIAILVLLL LLGIGLMWWF WPLCCKVVIK DPPPPPPPAP
KEEEEEPLPT KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVKIPE
EPEEPVRPRP PRAKPTHQPP QTKWYTPIKG RLDALWALLR RQYDRVSLMR PQEGDEGRCI
NFSRVPSQ
//
