ID K9J5S1_DESRO Unreviewed; 575 AA.
AC K9J5S1;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=PC4 and SFRS1-interacting protein {ECO:0000256|ARBA:ARBA00039324};
DE AltName: Full=Lens epithelium-derived growth factor {ECO:0000256|ARBA:ARBA00041831};
DE Flags: Fragment;
OS Desmodus rotundus (Vampire bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC Desmodontinae; Desmodus.
OX NCBI_TaxID=9430 {ECO:0000313|EMBL:JAA52289.1};
RN [1] {ECO:0000313|EMBL:JAA52289.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:JAA52289.1};
RA Francischetti I.M.B., Assumpcao T.C.F., Ma D., Vicente E.C.,
RA Ribeiro J.M.C.;
RT "The Vampirome: Transcriptome and Proteome Analysis of the Submandibular
RT and Accessory Glands of the Vampire Bat and Vector of Human Rabies,
RT Desmodus rotundus.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HDGF family.
CC {ECO:0000256|ARBA:ARBA00005309}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GABZ01001236; JAA52289.1; -; mRNA.
DR AlphaFoldDB; K9J5S1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd20151; PWWP_PSIP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF42; PC4 AND SFRS1-INTERACTING PROTEIN; 1.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 56..113
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA52289.1"
SQ SEQUENCE 575 AA; 65018 MW; B12A38C9D5AD1F85 CRC64;
NTPRHPRAPG APEPRFQSVQ SRSIPHAVHT SAPSFWSSAP DPRHRPSRNM TRDFKPGDLI
FAKMKGYPHW PARVDEVPDG AVKPPTNKLP IFFFGTHETA FLGPKDIFPY SENKEKYGKP
NKRKGFNEGL WEIDNNPKVK FSSQQASAKQ SNASSDVEIE EKETSVSKED TDHEEKASNE
DVTKAMDITT PKAARRGRKR KAEKQVEAEE AGVVTTATAS ANLKVSPKRG RPAATEVKIP
KPRGRPKMVK QNCPSESDIV TEEDKGKKKG QEEKQPKKQL KKDEEGQKEE DKPRKEPDKK
EGKKEVESKR KNLAKSGVTS TSDSEEEGDD QEGEKKRKGG RNFQTAHRRN MLKGQHEKEA
ADRKRKQEEQ METEQQNKDE GKKPEVKKVE KKRETSMDSR LQRIHAEIKN SLKIDNLDVS
RCIEALDELA SLQVTMQQAQ KHTEMITTLK KIRRFKVSQI IMEKSTMLYN KFKNMFLVGE
GDSVITQVLN KSLAEQRQHE EANKTKDQGK KGPNKKLEKE TGSKTLNGGS DQDSNQPQHN
GDSNEDSKDE ASSKKKPSSE ERDPEISLKD STLDN
//
