ID K9J6B3_DESRO Unreviewed; 1532 AA.
AC K9J6B3;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Putative guanine nucleotide exchange factor {ECO:0000313|EMBL:JAA53249.1};
DE Flags: Fragment;
OS Desmodus rotundus (Vampire bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC Desmodontinae; Desmodus.
OX NCBI_TaxID=9430 {ECO:0000313|EMBL:JAA53249.1};
RN [1] {ECO:0000313|EMBL:JAA53249.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:JAA53249.1};
RA Francischetti I.M.B., Assumpcao T.C.F., Ma D., Vicente E.C.,
RA Ribeiro J.M.C.;
RT "The Vampirome: Transcriptome and Proteome Analysis of the Submandibular
RT and Accessory Glands of the Vampire Bat and Vector of Human Rabies,
RT Desmodus rotundus.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; GABZ01000276; JAA53249.1; -; mRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13390; PH_LARG; 1.
DR CDD; cd08754; RGS_LARG; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR037801; ARHGEF12_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037884; LARG_RGS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 62..126
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 776..966
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1008..1121
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 196..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA53249.1"
SQ SEQUENCE 1532 AA; 173253 MW; 8E9303FD83E6A433 CRC64;
RFPLKKPIRH GSILNRESPT DKKQKVERSV SHDFDPTDSS SKKTRSSSEE SRSEIYGLVQ
RCVVIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT LVTHSNHLEV
VKLIKSGSYV ALTVQGRPPG SAQIPLSDSE VEPLVIGHMS PIMTSPHSPG TSGNMERITS
PVLMEEENNV VHNQKVEILR KMLRKEQERL QLLQEDYNRT PAQRLLKEIQ EAKKHIPQLQ
EQLSKATGSA QDGAIITSSK PLGDTLTVSE LEADPGDGLC KIDYSRDVSW PSSDNANSPK
SGQKEKIYLE ENLEKNEVIQ DTDTQSLIGS PSTHTAPHII GAEDDDFGTE HEQINGQCSC
FQSIELLKSR PAHLAVFLHH VVSQFDPATL LCYLYSDLYK QTNSKETRRV FLEFHQFFLD
RSAHLKVSVP DEISVDLEKR RPELIPEDLH RHYIQSVQER VHPEIQRHLE DFRQKRSMGL
TLAESELTKL DVERDKDRVT LEKERACAEQ IVAKIEEVLM TAQAIEEDKS STMQYVIFMY
MKHLGVKVKE PRNLEHKRGR IGFLPKIKQT MKKDREGEEK GKRRGFSSIL GPPRRPSRHD
NSAIGRAMEL QKQRYPKHLS TPSSVSPEPQ DSAKLRQSGL ASEGSDIGYL PANSMSSMAS
VATLFQEGGK DNDMGSKQVG ETPASGDSLD STPRTSNTIF DFLPLQLDQV QEEEWEVERI
PEHGTPKPFR KFDSIGFGES QSEDELFEND LETDPPNWQQ LVSREVLLGL KPCEIKRQEV
INELFYTERA HVRTLKVLDQ VFYQRVSREG ILSPSEIRKI FSNLEDILQL HIVLNEQMKA
VRKRNETSVI DQIGEDLLTW FSGPGEEKLK HAAATFCSNQ PFALEMIKSR QKKDSRFHTF
VQDAESNPLC RRLQLKDIIP TQMQRLTKYP LLLDNIAKYT EWPMEREKVK KAADHCRRIL
NYVNQAVKEA ENKQRLEDYQ RRLDTSNLKL SEYPNVEELR NLDLTKRKMI HEGPLVWKVN
RDKTIDLYTL LLEDILVLLQ KQDDRLVLRC HSKILASTAD SKHTFSPVIK LNTVLVRQVA
TDNKAFFVIS MSDNGAQIYE LVAQTVSEKT VWQDLICQMA ASVKEQSTKP IPLPQSPPCE
GDNDEEPPKI KVEHHGISVT CLQSTDRDLG LESPLMSSKA QPHSLDVSEK SEVDDLFVAE
RQFAKEQHAE GTVKKVGVKY PITIPDSHLP VSEGQWALDA LRNLGLLKQL LVQKLSLTEK
STQEDWPHFS TYRTASPGVQ TDSGTQNFEI IKAYHTGERQ RPFRTGTGDI SACYSPRAST
DSYVPRDSVV LAFQDSQASN ILVMDHMIMT PEIPPAEPEG GLDESGEHFF DAREVHSDDN
PLEGDGAVKM EEKDANLHIS GNYLILDGYE TVQESSTDEE VTSSLPPQPM KGLPFVDSTQ
QPQHSLQNAL SDGAVSPFTP EFLVQQCWEA GEDTCYEIQS PYTCADSERQ IMEYIHKIEA
DLEHLKKVEE SYTILWQRLA ESALTDNHSD KS
//
