ID K9NW04_COLAN Unreviewed; 413 AA.
AC K9NW04;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AFY23788.1};
OS Colobus angolensis (Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=54131 {ECO:0000313|EMBL:AFY23788.1};
RN [1] {ECO:0000313|EMBL:AFY23788.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23166696; DOI=10.1371/journal.pone.0049521;
RA Springer M.S., Meredith R.W., Gatesy J., Emerling C.A., Park J.,
RA Rabosky D.L., Stadler T., Steiner C., Ryder O.A., Janecka J.E.,
RA Fisher C.A., Murphy W.J.;
RT "Macroevolutionary dynamics and historical biogeography of primate
RT diversification inferred from a species supermatrix.";
RL PLoS ONE 7:E49521-E49521(2012).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; JX856258; AFY23788.1; -; Genomic_DNA.
DR AlphaFoldDB; K9NW04; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF84; COLLAGEN ALPHA-1(XXI) CHAIN-LIKE ISOFORM X1; 1.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 261..413
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFY23788.1"
FT NON_TER 413
FT /evidence="ECO:0000313|EMBL:AFY23788.1"
SQ SEQUENCE 413 AA; 45920 MW; 7E10798D80D0DCDD CRC64;
QEPGGLVMPP TDAPVSPTTP YVEDVSEAPL HDFYCSKLLD LVFLLDGSSR LSEAEFEVLK
AFVVDMMERL RISQKWVRVA VVEYHDGSHA YIGLKDRKRP SELRRIASQV KYAGSQVAST
SEVLKYTLFQ IFGKIDRPEA SRIILLLMAS QEPQRMSRNF VRYVQGLKKK KVIVIPVGIG
PHANLKQIRL IEKQAPENKA FVLSGVDELE QQRDEIVSYL CDLAPEAPPP TLPPDVAQVT
VGPGLLGVST LGLKRNSMVL DVAFVLEGSD NIGEADFNRS KEFMEEVIQR MDVGQDGIHV
TVLQYSYTVA VEYPFSEAQS KGDILQRVRE IRYQGGNRTN TGLALQYLSE HSFLVSQGDR
EQAPNLVYMV TGNPASDEIK RLPGDIQVVP IGVGPHANVQ ELERIGWPNA PIL
//
