ID K9P7Q4_CYAGP Unreviewed; 616 AA.
AC K9P7Q4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:AFY28993.1};
GN OrderedLocusNames=Cyagr_1855 {ECO:0000313|EMBL:AFY28993.1};
OS Cyanobium gracile (strain ATCC 27147 / PCC 6307).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Cyanobium.
OX NCBI_TaxID=292564 {ECO:0000313|EMBL:AFY28993.1, ECO:0000313|Proteomes:UP000010388};
RN [1] {ECO:0000313|Proteomes:UP000010388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27147 / PCC 6307 {ECO:0000313|Proteomes:UP000010388};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
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DR EMBL; CP003495; AFY28993.1; -; Genomic_DNA.
DR AlphaFoldDB; K9P7Q4; -.
DR STRING; 292564.Cyagr_1855; -.
DR KEGG; cgc:Cyagr_1855; -.
DR PATRIC; fig|292564.3.peg.1763; -.
DR eggNOG; COG1010; Bacteria.
DR eggNOG; COG2073; Bacteria.
DR HOGENOM; CLU_009721_2_1_3; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000010388; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFY28993.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFY28993.1}.
FT DOMAIN 46..124
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 217..357
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 370..579
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 616 AA; 64390 MW; 7C2FFBBB90254E6A CRC64;
MSDPTRRHIG LGFSPTATAM LQRLRQAGLL HVVREAEAEA EASGPWLARQ WGTADAVVAV
GACGLVTRLI APLISDKQSD PAVLVVDPRG RFVVPLLGGH GAGGDRLAEE IAALVGGQAV
LTGAGASLGR LPLDAFGQAW GWRRGAGDWR GLMVQAAGGL PPFLSQEAGT TLWQGLEAAG
SGKDNSDGDD SNQADGEAAL VIGPRSGAGC RWHPPSLWLG IGCERDTSLP VLERLVAEGL
AQQGLAREAV AGLASIDRKG DEPALLALAE QHGWPLRLYD ASTLAAVAVP HPSEAVAREM
GTPSVAEAAA LQAASEAASE AGQPLTHLAG TAPRLLVEKR IGRAASGERG AATLAVALAA
RQWAPQRGSL HLVGSGPGPI DLLSGDARRA LAATTVWVGY GLYLDLLEPL RRPDQLRREG
RLTEERARCA EAIDLARQGL DVALISSGDS GIYGMAGLAL ELWLQLPVLD RPAFTVHPGL
SALQLAAARA GAPLMHDFCT ISLSDRLTPW EVIERRLKGA ASGDFVVALY NPRSLGRPWQ
LGRAIELLVE GRPASTPVLL ARQLGRAEEA LSLHTLGNLP EDQVDMLTLV LVGNSSTRVQ
DGRMVTPRGY PGAALA
//
