ID K9QQJ2_NOSS7 Unreviewed; 5626 AA.
AC K9QQJ2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=CARDB domain-containing protein,putative collagen-binding protein,Calx-beta domain-containing protein,subtilase family protease {ECO:0000313|EMBL:AFY47683.1};
GN OrderedLocusNames=Nos7524_1819 {ECO:0000313|EMBL:AFY47683.1};
OS Nostoc sp. (strain ATCC 29411 / PCC 7524).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=28072 {ECO:0000313|EMBL:AFY47683.1, ECO:0000313|Proteomes:UP000010378};
RN [1] {ECO:0000313|Proteomes:UP000010378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29411 / PCC 7524 {ECO:0000313|Proteomes:UP000010378};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CP003552; AFY47683.1; -; Genomic_DNA.
DR RefSeq; WP_015138135.1; NC_019684.1.
DR STRING; 28072.Nos7524_1819; -.
DR KEGG; nop:Nos7524_1819; -.
DR PATRIC; fig|28072.8.peg.1976; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG1572; Bacteria.
DR eggNOG; COG2374; Bacteria.
DR eggNOG; COG2931; Bacteria.
DR eggNOG; COG3209; Bacteria.
DR eggNOG; COG3291; Bacteria.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_223128_0_0_3; -.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000010378; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 1.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR011635; CARDB.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR033764; Sdr_B.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF13229; Beta_helix; 1.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF07705; CARDB; 16.
DR Pfam; PF00353; HemolysinCabind; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF17210; SdrD_B; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00237; Calx_beta; 1.
DR SMART; SM00710; PbH1; 6.
DR SUPFAM; SSF51120; beta-Roll; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR SUPFAM; SSF117074; Hypothetical protein PA1324; 2.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Collagen {ECO:0000313|EMBL:AFY47683.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000010378};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 5260..5362
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 4338..4389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5222..5241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4345..4366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4919
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 4961
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 5147
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 5626 AA; 599541 MW; AC20301D13480C8A CRC64;
MHTVSHETWQ NLTPVPFTYG VSAGGGLATD GVYIYAADFS ADSDDDYIDL DGDLIDDPEE
RLDALRLDAL VITNGSVRFG RYNPDTDSWE SLPTLNLTGV DGDAFSSGNL VNPLFVVGSK
LYYYQFRSGP NIRALYSYDL TSGVEGTWQS VWEKTSADNP LIDANAGIVG LDVDGQPVIL
HHTGGGDYNF ARTDDIADGG THTLLTPSWN FSGAHFPRGG DWEYDTSSDR LYHLSGDQLV
MWSHNDTNYP DGSFLTSTPD GTNPIAQETI VITSLADNLG WNTGSTQAYP GTSLWGNSVT
IANDSLYLIR GETSTDGWPF NEGRGIINNG NFARILPNGW LETLPNTPFN IGKGSSAVYL
NGYLYVTQGD TLTANDPDNV SPLNQEGIRS PGKGFARFAI AASPNVGTTY TVTNTDDSGE
GSLRWAIEQA NTNVGTDTIL FNIPGIEPQT INVSSQLPEI TEAVFLDATS QPTYQGSPVI
VLNGSAAGAD AVGLNITAGN STIRGLAIYG FSGWGMRLTG GGNNTIQGNI IGDGGGGIYI
TSALNLIGGA TVTESNAIAN NNNIGISISA LTATGNQILN NLIQNNDAGV QISDGASNNL
ITENVISNNT NDGIAIVAGE SDATNNAIFG NNIYDNGGLG IDLGNDGVTT NDEGDSDGGA
NALQNYPVII SATLEGENTL IAGELNSLPS STYRIEIFSN SSIDISGNGE GENLLTSLVV
TTDESGNASF SVTLPVMLPE EYYITATATD ALGNTSEFSA PIQIINNNLP DLIVGEVTAA
DTAALGETIS VSWTITNQGL GSAINSWYDE IYISDDQIFD DNDTYVEYNW SGEYIPLEPG
SSYTLNQDIY IPEYTTGGLR YLLFVTDVYD DQEEADETNN VVAQAINITA PNLVITSVTA
PTTAITGQSI DLTWVVTNQG AAPTSIDNSW YDYIYFSRND ILGDDDDVYI TNIWSSDYAS
LPLNPAENYT VEQSVFLPSE ALGSGYLLFA TDRWEYQGES HETDNVFAQA IDIAAPDLIV
SAATAPPSGV VGEIISVSWT VRNQGTVTAS RDWQDRIYIS DDETLDGSDT FITSQSITSQ
TPLAADASYS ITQDITLPNT TLGNRYLLFV ADGNNAQGET DETNNVQAVA IELSAPDLVV
STATAPASGV VGEIISVSWT VRNQGAVTAF RDWQDRIYIS DDETFDGSDT FIVSQSITSQ
TPLAADGSYN ITRTITLPNT TLGNRYLLFV ADGNNAQSET DETNNVRAVA IELGAPDLVV
TAATAPASGV VGEIISVSWT VTNQGTVTAS RDWQDRIYIS DDETFDGSDI FITSRSITSQ
TPLAADASYS ITQDITLPNT TLGNRYLLFV ADGNNAQGET DETNNVQAVA IELSAPDLVV
STATAPASGV VGEIISVSWT VRNQGAVTAF RDWQDRIYIS DDETFDGSDT FIVSQSITSQ
TPLAADGSYN ITRTITLPNT TLGNRYLLFV ADGNNAQSET DETNNVRAVA IELGAPDLVV
TAATAPASLT LGGTTDLSWT VSNIGNSPAP SDWFDRVYLS NDTTFDSSDT LLTSQSAAAS
TPLAVGDSYT LSATNVTVPL TDTGDRYLLF VADATSNQGE TNENNNVFSL PVTIAGALPG
ARSATVSGDV FLGGNYIELG LSRWGSFGTN ATKPSNFYGT NARSQIGMSA DFDGFLNGQD
LRFDYFLPGS PEERWVIGYQ AGGSTFTASN AARTGSTQIS NSVTNTSTSD QLSAVSTGSY
NNTLGITQQI GFRVDDKYFR NIVTLTNISA QTLNSVRYMR SVDPDNTVDL GGSFTTDNIV
QATIAEDGRA IVEARTTSDS DPVFQRTGSR APIFFYSNDP RAVASTFGFT NTNPYAPLAY
DTPATRGQTI RDDQAITLTF DVGTLLPGEA ATFVYYTSLD DRNFEDVIEE LERPDLTVTS
VTPGANPAEF GSSLDISWVI ANNGLRETTG GWTDRIYLSS DATLSGDDLL LSSLPTGETT
LFPSGNISRT TSINLPFDDN STAGSYYILV QADALGNQLE SVETNNVRAA AIELTLPPLP
DLVISDATAP ASLILGQTGS ISWTVTNQGV GVASEDWSDR VYLSVDDILD DSDILLLTET
IASQTPLDAA SSYTISRNFT PGSTLTPGAY NLLIVTDSDR IQRESDETNN LRFVPLSINA
PDLVVSSITA PVESVSGQPL EISWTVTNQG QAATGGTWTD YVYLVNADTG AFVRNVGNFS
FTGTLAAGAS INRTQSYNVP LELAGNFRVV VRTDNNNNIP EGTPNEANNT TIGDRPITIR
LAPIPNLQIS SVTTPTTAFS SQQTVVSWQV TNTGNGATSA PIWYDAVYLS LDTTFDDTDV
FLGEAANSSY LNSGESYTNS LSVTLPRGID SNYYFLVKTD SRNNVNELSN EGDNFGVGGP
TRINLTPPPD LQVTNVNAPA MTFSGQPMNL SWTVTNEGPG RTLETAWYDR IFMSEDEILD
SGDRSLAEIF RNGALNSGES YTASTTVNLP IGVSGNYYFF VRTDSRNQVY ENIFENNNVN
YDTTATVITL TPPPDLEVDF VTIPNTARAG SNITINYGVT NYGASETPNF SWQDTFYLSL
DNQFDPTTDI RLGNVTRFGA LNPDQGYERT VNFTLSNTLA GNYYLFVTTD SSDQVFELDN
ANNTRRSNNQ VQITASPADL VVNTTTVPTT GEAGKSLRVQ WSVSNQGTGD TIVTSWTDRI
IASTDGVLGN ADDVVLANFN RTGILNPGNS YSREEFVNLP FALEGNYQLF VVTDAGNTVY
EASNENNNAS VAIPVTISRQ TPDLQVTQIN VPATVSSGTP LTISWTVQNL GTGRTNSNFW
YDDVYLSVDP NISASDIKLG SFYRSGALEP TVEYTATANF NLPIDLNGSY YVIVRTDRNN
LVTEGALENN NDQASDSTVA VSLSPVPDLV VDAVDAPEQA IAGQPFSLTW TVTNNGAVTT
GTWYDAFYLS RDQVFDRNSD IYLGFQNRTA LGAGESYTTT QAFNLPRGLA GLFYVFAVTD
GGNAIYERNG ENNNTNYDGF SMEVILPPPS DLVVTDIVVP TNAVPGQPIT INYTVQNQGT
DAALGSWYDA VYISADNQWD IGDALVGQVL RSGTIASGNS YSGTITANLP GVTPGNYYAI
VRSDIRNQVP EINEANNTGV STNQVSIDAE QLIIDVADTA TLRQGQSIYY RFNATAGQTI
RLRLDSQNNQ SFNELYVRQG AMPSRGEFDV TGIEPFTADP EILLPITQDG TYYVLAYGAQ
ATSPAEYTIV AEDVPLSILD VSTNRIGNSG SATLSILGAR FTEDTIFQLI SPDGDVIAAG
QVYLANSTQA FATFDLFNQD VGLYDVRAIQ GFDASARLED VVTVEAGTGF RLSSSLNGQQ
EVRPNRNYLF NVDYGNAGDS DTKAPLLIVQ SATNTPLGLE LNNLGAGAPL HLLGVSFDGP
LNILRPGDTN SIPVYFNSAT NEVNFSISTY SVENSTSIDL NSFEASIRPA GLTDAQWNSF
IADIAPRVQT YGQYANLLND LSEQLSGTGQ PIYDVRELFA RAYSENANFF ATATLAGELR
NASNNSAIAN TEIAAYRLID GGMELAGITT TNDQGQFQFS YLTNGQYEII PTAPYVFDNN
RDSIPDSVRP TFTITDTSVV SAGTLYADIP TAAPPIIQES TPSLARDSAG NLHLLWTREG
QLWHAVNNGS GFEAQPLSQA FGSDVKLLIN PNLINGTSEG LIATWSSGEG NESEIYYAIG
QATAGGGYQW TAPIQLTNNS LYDGAFDLEI TDNGTPLFIW QRQDFSIEDD ADLYYGGITV
ENPEFLDPLS NVTILTTVAN ALQYSDAELE ALGIHRVRYA QDLGRITIPS WVPFISGTYE
AQFRADLVGQ IDCTLILGAN GQLRFKVGDN GELTGEVGGQ ARWTTNDDCE YEFQNARIRG
VVAGGLNIPL TDYRLGPFAG IKIGPRIELA GGANLIWDAG SDFPSWPSRV EGSFRGSLGA
NVEGKVSIPI LGEVKVTGRV LGNFNFKADA NGLGPADPFF SVSVLLRAEA TVFGRKRFID
WTGTWPGQDL GGQSVDGFMP SDLFGFSEQT FYDETLIFSI STDVDTGTLN DYSDDNASAL
TANLYEEGTP VLTKDNNGIL YAGWTNQDGV VISQLNAATG QWLAPSVIAG SAGLANSDLV
LAFDGDGDGL AVWSSQDVSG LNENNSQEEI RNSFIVGGDL VFSVYDATTT TWSSASPLFT
LTGADRSLAL GKDTDGNLVA SWLHDHNDRQ STLYATIWDA DTNVWSAPAT IASGFFSGQP
SVSALGAQPI IMWTQDDEAG INVVQANQSL KYSLFDGVAW STPLDFTYSI NEALAQNAIS
IFSDSSDFSE LFGSSIPLPS PPEECCDCEE GDPECDDDDD DNNDDDNYDP PVRRPSDPND
ILGPEGFGDE RWINARNPLA YTIRFENEPT ASAPAQEVII TQYLDADLDW RTFRIDDFGW
GDLRFDLPGD RSFYSNRIDL RATQGFYVDV SASIDVLTGL ATWRIATVDP TTGEAPLDAQ
TGFLPINDEN GLGEGFVSYS VRTKRDITTG SVIDAEARIV FDTEAPIDTP PIFNTIDVGV
PTSSVTSLPE VSDSPEFLVT WSGSDDPNGS ALAGYTIYVS VNAGAFTPWL TNTTLTEATY
IGELGNTYSF YSVAADHAGN VEAPPTTADA LIRVAGGLAS LGDLVWVDSN ANGLRDADEP
GLAGVSINLY DGSNTLVATT TTDTNGIYSF TDLNPGDYVV EFVPGTGYLF SPQNQGSNSA
LDSDADPTSG RSLTVTLNPR DNNLTVDAGV YQFATIQGQK FHDLDGDGVK DPTEPGLSGW
TIYLDANRNG QLDTSEISTV TDANGNYIFT DLKPGTYNVA EVMQPGWQQT FPGTSNSNAA
ISTSASDAEL YTPSASVTTT ATSASPTASV SSLINLSNFR ADPRFTDIDG SGFAVVTIDT
GIDLNHPFFG PDLDGNGIAD RIVYQHDFGD RDNNASDLNG HGSHVASIIG SSDNTYTGVA
PGVNLIALKV FRDNGSGYFS DLEKSLQWVV ANAQTHNIAS VNLSLGDGRN WSTAGSYYGI
GDELAALAAM NIIVTAAAGN SFYEFNSWQG VAYPAADPNT IAVGAVWSDN LGGIWNFSNG
AQDYTTAADR IASFSQRDAD LLDVFAPGTR IIGANANGGT STLTGTSQAA PYIAGVAALA
QQLAVQQLGR QITVAEFREL LATTGVMIND GDNEDDNVTN TGINFARVNV LALAEKILTL
SPEAPTSGTT GSGTTGPGST PTLGAQSLTH TINLTSGQVV TGIDFGNQRL AEMATLTFSA
AAYSVNEDST SVTSITITRT SSNGTLTATL TLADGTATAP ADYDNTPIIV EFADGEASKI
VTIPIIDDAV VEGNETLSIS LGASSSYELG DITTATVTIV DNDIASVTIT ESDGSTNVTE
GGATDSYTVV LTSQPTADVS ITINGDSQVS TDVNTLTFTA ANWNVAQTVT VTAVDDEAFE
GNHSSTLTMT AASSDAKYDG IAIASVNVNI TDNDTIINGT SGSDTLIGTN GNNIITGFQG
ADILTGGEGK DQFVYTSIRD AGDTITDFVP GTDTIVLTQL FQSLRLSHLN YETATAQGYL
RFGTNSAGGT VLIDPDGFIG RAATTTLLTV QGVSQNDLAS VNNFIF
//
