ID K9RQE2_SYNP3 Unreviewed; 703 AA.
AC K9RQE2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Kef-type K+ transport system, membrane component {ECO:0000313|EMBL:AFY59312.1};
GN OrderedLocusNames=Syn6312_0056 {ECO:0000313|EMBL:AFY59312.1};
OS Synechococcus sp. (strain ATCC 27167 / PCC 6312).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=195253 {ECO:0000313|EMBL:AFY59312.1, ECO:0000313|Proteomes:UP000010379};
RN [1] {ECO:0000313|Proteomes:UP000010379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27167 / PCC 6312 {ECO:0000313|Proteomes:UP000010379};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003558; AFY59312.1; -; Genomic_DNA.
DR AlphaFoldDB; K9RQE2; -.
DR STRING; 195253.Syn6312_0056; -.
DR KEGG; syne:Syn6312_0056; -.
DR PATRIC; fig|195253.3.peg.61; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_017738_0_0_3; -.
DR Proteomes; UP000010379; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd01988; Na_H_Antiporter_C; 1.
DR CDD; cd00293; USP_Like; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43562:SF4; NA(+)_H(+) ANTIPORTER NHAS5; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010379};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..400
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 435..566
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
FT DOMAIN 575..697
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 703 AA; 75737 MW; B7918146049EF563 CRC64;
MLGFSVPWLY SGLGQLVLGG LVLLDNPVFI FTILIAVSLS IPPIFERIKL PGLVGLLLAG
IILGPSGLQF LNHKTETMVL LSGVGKIYLM FVAGLEIDLS QFRKTRNRSM GFGFLTFIVP
LMTGMVVGRW FGFGWNGALL IGSLFASHTL LAYPIVSRLG VVQNEAITVT IGATIFTDTA
ALLVLAICVG IAAGNFTAWS LMLLLVALAV YSVAVLWGID RVGKEFFRRS GDNEGNQFLF
VLLALFVASV GAQVIGIEQI VGAFLAGLAV NDVIGESPVK EKVEFVGGVL FIPFFFIDMG
LLIDLPAFLK TLSSWGLTLA IVGGLIGSKF VAAWLASVIY RYSRVEMLSM WSLSLPQVAA
TLAATLVGYQ QGILTQDILN SVIVLMVVTS ILGPLITSRV ASRIPVPQPE TDTVDELWRD
TAGLEGETDD SAPFTVIVPV QNPQTERSLI QLAALLARHE QGRVVPLVVT RAAVHMDDPG
LETSLQRGQK LLRRAVEIGQ AYAVPLEPQL RIDDDVPLGI TRLSREENSN LIIVGWSEKT
GLRARLFGTV IDSILWSAHC PVAITRLLDE PENIQSILVP VRDLTAPTLR IVGFAQALAA
ASQADVTLLH VCLPGIPSEQ MTQFEAELAR ILPPDSRPVC IDIQTVAESD IASAILGQAA
SRDLVLMRSI RRRTTGGLAV SDITTQVVKE LPCSVILFGE PHS
//
