ID K9X471_9NOST Unreviewed; 579 AA.
AC K9X471;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=Cylst_4844 {ECO:0000313|EMBL:AFZ26899.1};
OS Cylindrospermum stagnale PCC 7417.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC Cylindrospermum.
OX NCBI_TaxID=56107 {ECO:0000313|EMBL:AFZ26899.1, ECO:0000313|Proteomes:UP000010475};
RN [1] {ECO:0000313|EMBL:AFZ26899.1, ECO:0000313|Proteomes:UP000010475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7417 {ECO:0000313|EMBL:AFZ26899.1,
RC ECO:0000313|Proteomes:UP000010475};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Chen A., Kyrpides N.,
RA Mavromatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Pati A.,
RA Goodwin L., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T., Kerfeld C.A.;
RT "Finished chromosome of genome of Cylindrospermum stagnale PCC 7417.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; CP003642; AFZ26899.1; -; Genomic_DNA.
DR AlphaFoldDB; K9X471; -.
DR STRING; 56107.Cylst_4844; -.
DR KEGG; csg:Cylst_4844; -.
DR PATRIC; fig|56107.3.peg.5320; -.
DR eggNOG; COG1293; Bacteria.
DR HOGENOM; CLU_022481_1_0_3; -.
DR Proteomes; UP000010475; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000010475};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 461..554
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 579 AA; 66317 MW; 3B7C3E4310517B1D CRC64;
MNLRCIPVDF TTLTAACSDL RANWLPSRTE QVYQRDRYTI AVALRTLETR VWLNICWHPQ
AAHICIGEPP PRLQDTFTFS QQLVHQLGGL ALVGIEAIAP WERVVDLQFA RRPGESALYH
LYVEVMGKYS NAILTDASNI IITAAHQVSQ QQSSVRPIQT GQPYEIPPKL TGPIPNLSES
LERWQERVSL VPGAIKKQLL KSYRGLSAAL LDSMLLAANL APETTTDTLT PDDWKKLFER
WQEWLQALEI GKFQPAWTKD GYTVMGWGAI DTTKDIQELL NRYYTNQINQ QLFSQVRHQL
SQKLQNILAK LRLKRQTFSD RLQQSDQADE WKQKADLMMA NLQNWQPGMK EIILPDFDSG
KPVAIALLPD KNAVQNAQKL YKQHQKLKRA RAAVEPLFLE VQAEVEYLEQ VEAAISQIDN
YQTTEDLQAL EEIRDELIGQ KYLEDPEYRN RITTERASTN FHRYRSPSGF EVLIGRNNRQ
NDHLTFRVAG DYDLWFHAQE IPGSHLLLRL EPGTVPEEAD LQFTANLAAY FSRARQSDQV
PVVYTQPKHV YKPKGAKPGI AIYKQETILW GKPQSVNSH
//
